Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HD022082-20
Application #
6858653
Study Section
Allergy and Immunology Study Section (ALY)
Program Officer
Moody, Sally Ann
Project Start
1987-04-01
Project End
2009-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
20
Fiscal Year
2005
Total Cost
$462,377
Indirect Cost
Name
Immune Disease Institute, Inc.
Department
Type
DUNS #
059709394
City
Boston
State
MA
Country
United States
Zip Code
02115
Mejia, Pedro; Diez-Silva, Monica; Kamena, Faustin et al. (2016) Human C1-Inhibitor Suppresses Malaria Parasite Invasion and Cytoadhesion via Binding to Parasite Glycosylphosphatidylinositol and Host Cell Receptors. J Infect Dis 213:80-9
Lu, Fengxin; Fernandes, Stacey M; Davis 3rd, Alvin E (2013) The effect of C1 inhibitor on myocardial ischemia and reperfusion injury. Cardiovasc Pathol 22:75-80
Davis 3rd, Alvin E; Lu, Fengxin; Mejia, Pedro (2010) C1 inhibitor, a multi-functional serine protease inhibitor. Thromb Haemost 104:886-93
Davis 3rd, Alvin E; Mejia, Pedro; Lu, Fengxin (2008) Biological activities of C1 inhibitor. Mol Immunol 45:4057-63
Davis 3rd, Alvin E (2008) Hereditary angioedema: a current state-of-the-art review, III: mechanisms of hereditary angioedema. Ann Allergy Asthma Immunol 100:S7-12
Davis 3rd, Alvin E; Cai, Shenghe; Liu, Dongxu (2007) C1 inhibitor: biologic activities that are independent of protease inhibition. Immunobiology 212:313-23
Liu, Dongxu; Lu, Fengxin; Qin, Gangjian et al. (2007) C1 inhibitor-mediated protection from sepsis. J Immunol 179:3966-72
Davis 3rd, Alvin E (2006) Mechanism of angioedema in first complement component inhibitor deficiency. Immunol Allergy Clin North Am 26:633-51
Cai, Shenghe; Dole, Vandana S; Bergmeier, Wolfgang et al. (2005) A direct role for C1 inhibitor in regulation of leukocyte adhesion. J Immunol 174:6462-6
Liu, Dongxu; Zhang, Dong; Scafidi, Jennifer et al. (2005) C1 inhibitor prevents Gram-negative bacterial lipopolysaccharide-induced vascular permeability. Blood 105:2350-5

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