Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37HL005949-25
Application #
3485228
Study Section
Biophysics and Biophysical Chemistry B Study Section (BBCB)
Project Start
1975-05-01
Project End
1990-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
25
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Boston Biomedical Research Institute
Department
Type
DUNS #
058893371
City
Watertown
State
MA
Country
United States
Zip Code
Leszyk, J; Tao, T; Nuwaysir, L M et al. (1998) Identification of the photocrosslinking sites in troponin-I with 4-maleimidobenzophenone labelled mutant troponin-Cs having single cysteines at positions 158 and 21. J Muscle Res Cell Motil 19:479-90
Luo, Y; Wu, J L; Gergely, J et al. (1997) Troponin T and Ca2+ dependence of the distance between Cys48 and Cys133 of troponin I in the ternary troponin complex and reconstituted thin filaments. Biochemistry 36:11027-35
Tan, R Y; Mabuchi, Y; Grabarek, Z (1996) Blocking the Ca2+-induced conformational transitions in calmodulin with disulfide bonds. J Biol Chem 271:7479-83
Kobayashi, T; Grabarek, Z; Gergely, J et al. (1995) Extensive interactions between troponins C and I. Zero-length cross-linking of troponin I and acetylated troponin C. Biochemistry 34:10946-52
Grabarek, Z; Mabuchi, Y; Gergely, J (1995) Properties of troponin C acetylated at lysine residues. Biochemistry 34:11872-81
Kobayashi, T; Tao, T; Gergely, J et al. (1994) Structure of the troponin complex. Implications of photocross-linking of troponin I to troponin C thiol mutants. J Biol Chem 269:5725-9
Grabarek, Z; Tao, T; Gergely, J (1992) Molecular mechanism of troponin-C function. J Muscle Res Cell Motil 13:383-93
Mabuchi, K (1991) Heavy-meromyosin-decorated actin filaments: a simple method to preserve actin filaments for rotary shadowing. J Struct Biol 107:22-8
Kobayashi, T; Tao, T; Grabarek, Z et al. (1991) Cross-linking of residue 57 in the regulatory domain of a mutant rabbit skeletal muscle troponin C to the inhibitory region of troponin I. J Biol Chem 266:13746-51
Fuchtbauer, E M; Rowlerson, A M; Gotz, K et al. (1991) Direct correlation of parvalbumin levels with myosin isoforms and succinate dehydrogenase activity on frozen sections of rodent muscle. J Histochem Cytochem 39:355-61

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