Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL016346-26
Application #
2214975
Study Section
Special Emphasis Panel (NSS)
Project Start
1993-12-05
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
26
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Evanston
State
IL
Country
United States
Zip Code
60201
Lefebvre, Phil; Velasco, Pauline T; Dear, Amy et al. (2004) Severe hypodysfibrinogenemia in compound heterozygotes of the fibrinogen AalphaIVS4 + 1G>T mutation and an AalphaGln328 truncation (fibrinogen Keokuk). Blood 103:2571-6
Iismaa, Siiri E; Holman, Sara; Wouters, Merridee A et al. (2003) Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases. Proc Natl Acad Sci U S A 100:12636-41
O'Neill, Gerald M; Prasanna Murthy, S N; Lorand, Laszlo et al. (2003) Activation of transglutaminase in mu-calpain null erythrocytes. Biochem Biophys Res Commun 307:327-31
Lorand, Laszlo; Velasco, Pauline T; Hill, John M et al. (2002) Intracranial hemorrhage in systemic lupus erythematosus associated with an autoantibody against actor XIII. Thromb Haemost 88:919-23
Lorand, Laszlo (2002) Transglutaminase: remembering Heinrich Waelsch. Neurochem Int 40:7-12
Lorand, L (2001) Factor XIII: structure, activation, and interactions with fibrinogen and fibrin. Ann N Y Acad Sci 936:291-311
Lorand, L (2000) Sol Sherry Lecture in Thrombosis : research on clot stabilization provides clues for improving thrombolytic therapies. Arterioscler Thromb Vasc Biol 20:9-Feb
Lorand, L; Velasco, P T; Murthy, S N et al. (1999) Autoimmune antibody in a hemorrhagic patient interacts with thrombin-activated factor XIII in a unique manner. Blood 93:909-17
Lorand, L; Parameswaran, K N; Murthy, S N (1998) A double-headed Gly-Pro-Arg-Pro ligand mimics the functions of the E domain of fibrin for promoting the end-to-end crosslinking of gamma chains by factor XIIIa. Proc Natl Acad Sci U S A 95:537-41
Parameswaran, K N; Cheng, X F; Chen, E C et al. (1997) Hydrolysis of gamma:epsilon isopeptides by cytosolic transglutaminases and by coagulation factor XIIIa. J Biol Chem 272:10311-7

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