Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL018672-19
Application #
2215171
Study Section
Special Emphasis Panel (NSS)
Project Start
1976-06-30
Project End
1999-11-30
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Rice University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
050299031
City
Houston
State
TX
Country
United States
Zip Code
77005
Sung, Derek C; Bowen, Caitlin J; Vaidya, Kiran A et al. (2016) Cadherin-11 Overexpression Induces Extracellular Matrix Remodeling and Calcification in Mature Aortic Valves. Arterioscler Thromb Vasc Biol 36:1627-37
Lee, Cho-Yin; Lou, Jizhong; Wen, Kuo-Kuang et al. (2016) Regulation of actin catch-slip bonds with a RhoA-formin module. Sci Rep 6:35058
Bowen, Caitlin J; Zhou, Jingjing; Sung, Derek C et al. (2015) Cadherin-11 coordinates cellular migration and extracellular matrix remodeling during aortic valve maturation. Dev Biol 407:145-57
Lee, Cho-yin; Lou, Jizhong; Wen, Kuo-kuang et al. (2013) Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds. Proc Natl Acad Sci U S A 110:5022-7
Coburn, L A; Damaraju, V S; Dozic, S et al. (2011) GPIbýý-vWF rolling under shear stress shows differences between type 2B and 2M von Willebrand disease. Biophys J 100:304-12
Conway, Daniel E; Lee, Sungmun; Eskin, Suzanne G et al. (2010) Endothelial metallothionein expression and intracellular free zinc levels are regulated by shear stress. Am J Physiol Cell Physiol 299:C1461-7
Conway, Daniel E; Williams, Marcie R; Eskin, Suzanne G et al. (2010) Endothelial cell responses to atheroprone flow are driven by two separate flow components: low time-average shear stress and fluid flow reversal. Am J Physiol Heart Circ Physiol 298:H367-74
Conway, Daniel E; Sakurai, Yumiko; Weiss, Daiana et al. (2009) Expression of CYP1A1 and CYP1B1 in human endothelial cells: regulation by fluid shear stress. Cardiovasc Res 81:669-77
Williams, Marcie R; Sakurai, Yumiko; Zughaier, Susu M et al. (2009) Transmigration across activated endothelium induces transcriptional changes, inhibits apoptosis, and decreases antimicrobial protein expression in human monocytes. J Leukoc Biol 86:1331-43
Yago, Tadayuki; Lou, Jizhong; Wu, Tao et al. (2008) Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF. J Clin Invest 118:3195-207

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