Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL020476-20
Application #
2215352
Study Section
Special Emphasis Panel (NSS)
Project Start
1976-09-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Biochemistry
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
De Luca, J P; Garnache, A K; Rulfs, J et al. (1999) Wortmannin inhibits insulin-stimulated activation of protein phosphatase 1 in rat cardiomyocytes. Am J Physiol 276:H1520-6
Buczek-Thomas, J A; Miller Jr, T B (1995) Identification of the molecular basis for phosphorylase hypersensitivity in cultured diabetic cardiomyocytes. Mol Cell Biochem 145:131-9
Buczek-Thomas, J A; Miller Jr, T B (1995) Cyclic GMP accumulation in normal and diabetic primary culture adult rat ventricular cardiomyocytes: a minor role for nitric oxide in phosphorylase activation. Cell Signal 7:591-8
Miller, C; Rulfs, J; Jaspers, S R et al. (1994) Transformation of adult ventricular myocytes with the temperature sensitive A58 (tsA58) mutant of the SV40 large T antigen. Mol Cell Biochem 136:29-34
Jaspers, S R; Garnache, A K; Miller Jr, T B (1993) Factors affecting the activation of glycogen synthase in primary culture cardiomyocytes. J Mol Cell Cardiol 25:1171-8
Buczek-Thomas, J A; Jaspers, S R; Miller Jr, T B (1992) Post-receptor defect accounts for phosphorylase hypersensitivity in cultured diabetic cardiomyocytes. Mol Cell Biochem 117:63-70
Buczek-Thomas, J A; Jaspers, S R; Miller Jr, T B (1992) Adrenergic activation of glycogen phosphorylase in primary culture diabetic cardiomyocytes. Am J Physiol 262:H649-53
Jaspers, S R; Miller Jr, T B (1991) Purification and the immunological characterization of rat protein phosphatase 2A: enzyme levels in diabetic liver and heart. Mol Cell Biochem 101:167-74
Klarlund, J K; Jaspers, S R; Khalaf, N et al. (1991) An insulin-stimulated kemptide kinase purified from rat liver is deactivated by phosphatase 2A. J Biol Chem 266:4052-5
Jaspers, S R; Rulfs, J; Johnson, G L et al. (1989) Amino-terminal sequence analysis of rat heart and muscle glycogen synthase: homology to the rabbit enzyme and the implications for hormonal control. Arch Biochem Biophys 268:630-6

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