Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37HL026057-14
Application #
2215950
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1981-07-01
Project End
1999-05-31
Budget Start
1994-07-01
Budget End
1995-05-31
Support Year
14
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Bidwell, Philip A; Haghighi, Kobra; Kranias, Evangelia G (2018) The antiapoptotic protein HAX-1 mediates half of phospholamban's inhibitory activity on calcium cycling and contractility in the heart. J Biol Chem 293:359-367
Liu, Guan-Sheng; Gardner, George; Adly, George et al. (2018) A novel human S10F-Hsp20 mutation induces lethal peripartum cardiomyopathy. J Cell Mol Med :
Kranias, Evangelia G; Hajjar, Roger J (2017) The Phospholamban Journey 4 Decades After Setting Out for Ithaka. Circ Res 120:781-783
Watanabe, Shin; Ishikawa, Kiyotake; Fish, Kenneth et al. (2017) Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure. J Am Coll Cardiol 70:1744-1756
Bidwell, Philip A; Kranias, Evangelia G (2016) Calcium Uptake in Crude Tissue Preparation. Methods Mol Biol 1377:161-70
Karakikes, Ioannis; Stillitano, Francesca; Nonnenmacher, Mathieu et al. (2015) Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy. Nat Commun 6:6955
Haghighi, Kobra; Pritchard, Tracy J; Liu, Guan-Sheng et al. (2015) Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias. J Mol Cell Cardiol 89:349-59
Liu, Guan-Sheng; Morales, Ana; Vafiadaki, Elizabeth et al. (2015) A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia. Cardiovasc Res 107:164-74
Tzimas, Christos; Terrovitis, John; Lehnart, Stephan E et al. (2015) Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions. Heart Rhythm 12:1599-610
Cai, Wen-Feng; Liu, Guan-Sheng; Lam, Chi Keung et al. (2015) Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility. Eur J Heart Fail 17:782-93

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