Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37HL028785-23
Application #
6695161
Study Section
Special Emphasis Panel (NSS)
Program Officer
Velletri, Paul A
Project Start
1989-04-01
Project End
2009-03-31
Budget Start
2004-04-15
Budget End
2005-03-31
Support Year
23
Fiscal Year
2004
Total Cost
$380,000
Indirect Cost
Name
University of Virginia
Department
Pharmacology
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Guyenet, Patrice G (2017) Putative Mechanism of Salt-Dependent Neurogenic Hypertension: Cell-Autonomous Activation of Organum Vasculosum Laminae Terminalis Neurons by Hypernatremia. Hypertension 69:20-22
Valentino, Rita J; Guyenet, Patrice; Hou, Xun Helen et al. (2017) Central Network Dynamics Regulating Visceral and Humoral Functions. J Neurosci 37:10848-10854
Stornetta, Ruth L; Inglis, M Andrews; Viar, Kenneth E et al. (2016) Afferent and efferent connections of C1 cells with spinal cord or hypothalamic projections in mice. Brain Struct Funct 221:4027-4044
Guyenet, Patrice G; Bayliss, Douglas A; Stornetta, Ruth L et al. (2016) Proton detection and breathing regulation by the retrotrapezoid nucleus. J Physiol 594:1529-51
Guyenet, Patrice G; Bayliss, Douglas A (2015) Neural Control of Breathing and CO2 Homeostasis. Neuron 87:946-61
Burke, Peter G R; Kanbar, Roy; Viar, Kenneth E et al. (2015) Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs. J Appl Physiol (1985) 118:1491-501
Holloway, Benjamin B; Viar, Kenneth E; Stornetta, Ruth L et al. (2015) The retrotrapezoid nucleus stimulates breathing by releasing glutamate in adult conscious mice. Eur J Neurosci 42:2271-82
Burke, Peter G R; Kanbar, Roy; Basting, Tyler M et al. (2015) State-dependent control of breathing by the retrotrapezoid nucleus. J Physiol 593:2909-26
Basting, Tyler M; Burke, Peter G R; Kanbar, Roy et al. (2015) Hypoxia silences retrotrapezoid nucleus respiratory chemoreceptors via alkalosis. J Neurosci 35:527-43
Burke, Peter G R; Abbott, Stephen B G; Coates, Melissa B et al. (2014) Optogenetic stimulation of adrenergic C1 neurons causes sleep state-dependent cardiorespiratory stimulation and arousal with sighs in rats. Am J Respir Crit Care Med 190:1301-10

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