Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37HL029851-18
Application #
2909292
Study Section
Special Emphasis Panel (NSS)
Project Start
1986-07-01
Project End
2005-05-31
Budget Start
2000-06-01
Budget End
2001-05-31
Support Year
18
Fiscal Year
2000
Total Cost
$263,565
Indirect Cost

  Institution

Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Randak, Christoph O; Welsh, Michael J (2005) ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity. Proc Natl Acad Sci U S A 102:2216-20
Randak, Christoph O; Welsh, Michael J (2005) Adenylate kinase activity in ABC transporters. J Biol Chem 280:34385-8
Berger, Allan L; Randak, Christoph O; Ostedgaard, Lynda S et al. (2005) Curcumin stimulates cystic fibrosis transmembrane conductance regulator Cl- channel activity. J Biol Chem 280:5221-6
Berger, Allan L; Ikuma, Mutsuhiro; Welsh, Michael J (2005) Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain. Proc Natl Acad Sci U S A 102:455-60
Randak, Christoph; Welsh, Michael J (2003) An intrinsic adenylate kinase activity regulates gating of the ABC transporter CFTR. Cell 115:837-50
Liu, Lei; Leonard, A Soren; Motto, David G et al. (2003) Contribution of Drosophila DEG/ENaC genes to salt taste. Neuron 39:133-46
Berger, Allan L; Ikuma, Mutsuhiro; Hunt, John F et al. (2002) Mutations that change the position of the putative gamma-phosphate linker in the nucleotide binding domains of CFTR alter channel gating. J Biol Chem 277:2125-31
Hennager, D J; Ikuma, M; Hoshi, T et al. (2001) A conditional probability analysis of cystic fibrosis transmembrane conductance regulator gating indicates that ATP has multiple effects during the gating cycle. Proc Natl Acad Sci U S A 98:3594-9
Cotten, J F; Welsh, M J (1999) Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR. Evidence for disruption of a salt bridge. J Biol Chem 274:5429-35
Hall, R A; Ostedgaard, L S; Premont, R T et al. (1998) A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proc Natl Acad Sci U S A 95:8496-501

Showing the most recent 10 out of 45 publications