Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL030340-14
Application #
2216617
Study Section
Special Emphasis Panel (NSS)
Project Start
1983-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Oklahoma Medical Research Foundation
Department
Type
DUNS #
937727907
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104
Cooper, Scott T; Rezaie, Alireza R; Esmon, Charles T et al. (2002) Inhibition of a thrombin anion-binding exosite-2 mutant by the glycosaminoglycan-dependent serpins protein C inhibitor and heparin cofactor II. Thromb Res 107:67-73
Carson, C W; Comp, P C; Rezaie, A R et al. (2000) Antibodies to thrombomodulin are found in patients with lupus anticoagulant and unexplained thrombosis. J Rheumatol 27:384-90
Kurosawa, S; Esmon, C T; Stearns-Kurosawa, D J (2000) The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18. J Immunol 165:4697-703
Yegneswaran, S; Smirnov, M D; Safa, O et al. (1999) Relocating the active site of activated protein C eliminates the need for its protein S cofactor. A fluorescence resonance energy transfer study. J Biol Chem 274:5462-8
Esmon, C T; Gu, J M; Xu, J et al. (1999) Regulation and functions of the protein C anticoagulant pathway. Haematologica 84:363-8
Smirnov, M D; Ford, D A; Esmon, C T et al. (1999) The effect of membrane composition on the hemostatic balance. Biochemistry 38:3591-8
Esmon, C T; Fukudome, K; Mather, T et al. (1999) Inflammation, sepsis, and coagulation. Haematologica 84:254-9
Rezaie, A R; He, X; Esmon, C T (1998) Thrombomodulin increases the rate of thrombin inhibition by BPTI. Biochemistry 37:693-9
He, X; Ye, J; Esmon, C T et al. (1997) Influence of Arginines 93, 97, and 101 of thrombin to its functional specificity. Biochemistry 36:8969-76
Yegneswaran, S; Wood, G M; Esmon, C T et al. (1997) Protein S alters the active site location of activated protein C above the membrane surface. A fluorescence resonance energy transfer study of topography. J Biol Chem 272:25013-21

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