Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL032723-13
Application #
2217072
Study Section
Special Emphasis Panel (NSS)
Project Start
1984-07-01
Project End
1998-03-31
Budget Start
1996-07-01
Budget End
1998-03-31
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111
Liu, Y; Fanburg, B L (2008) Phospholipase D signaling in serotonin-induced mitogenesis of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 295:L471-8
Merdek, Keith D; Jaffe, Aron B; Dutt, Parmesh et al. (2008) Alpha(E)-Catenin induces SRF-dependent transcriptional activity through its C-terminal region and is partly RhoA/ROCK-dependent. Biochem Biophys Res Commun 366:717-23
Finlay, Geraldine A; Malhowski, Amy J; Liu, Yingling et al. (2007) Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity. Cancer Res 67:9878-86
Liu, Yinglin; Fanburg, Barry L (2006) Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1. Am J Respir Cell Mol Biol 34:182-91
Preston, Ioana R; Hill, Nicholas S; Warburton, Rod R et al. (2006) Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol 290:L367-74
Schultz, Kelly; Fanburg, Barry L; Beasley, Debbie (2006) Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 290:H2528-34
Day, Regina M; Agyeman, Abena S; Segel, Michael J et al. (2006) Serotonin induces pulmonary artery smooth muscle cell migration. Biochem Pharmacol 71:386-97
Finlay, Geraldine A; Thannickal, Victor J; Fanburg, Barry L et al. (2005) Platelet-derived growth factor-induced p42/44 mitogen-activated protein kinase activation and cellular growth is mediated by reactive oxygen species in the absence of TSC2/tuberin. Cancer Res 65:10881-90
Fanburg, B L; Lee, S L (2000) A role for the serotonin transporter in hypoxia-induced pulmonary hypertension. J Clin Invest 105:1521-3
Lee, S L; Wang, W W; Finlay, G A et al. (1999) Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion. Am J Physiol 277:L282-91

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