Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL034787-12
Application #
2217662
Study Section
Special Emphasis Panel (NSS)
Project Start
1984-12-01
Project End
1997-12-31
Budget Start
1996-02-01
Budget End
1997-12-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Beacham, D A; Cruz, M A; Handin, R I (1995) Glycoprotein Ib can mediate endothelial cell attachment to a von Willebrand factor substratum. Thromb Haemost 73:309-17
Cruz, M A; Handin, R I; Wise, R J (1993) The interaction of the von Willebrand factor-A1 domain with platelet glycoprotein Ib/IX. The role of glycosylation and disulfide bonding in a monomeric recombinant A1 domain protein. J Biol Chem 268:21238-45
Petersen, E; Handin, R I (1992) Transient expression of recombinant glycoprotein Ib alpha polypeptides in COS cells that inhibit von Willebrand factor binding to the platelet glycoprotein Ib/IX complex. Thromb Haemost 68:203-7
Cruz, M A; Petersen, E; Turci, S M et al. (1992) Functional analysis of a recombinant glycoprotein Ib alpha polypeptide which inhibits von Willebrand factor binding to the platelet glycoprotein Ib-IX complex and to collagen. J Biol Chem 267:1303-9
Greenberg, S M; Chandrasekhar, C; Golan, D E et al. (1990) Transforming growth factor beta inhibits endomitosis in the Dami human megakaryocytic cell line. Blood 76:533-7
Ewenstein, B M; Inbal, A; Pober, J S et al. (1990) Molecular studies of von Willebrand disease: reduced von Willebrand factor biosynthesis, storage, and release in endothelial cells derived from patients with type I von Willebrand disease. Blood 75:1466-72
Michelson, A D; Adelman, B; Barnard, M R et al. (1988) Platelet storage results in a redistribution of glycoprotein Ib molecules. Evidence for a large intraplatelet pool of glycoprotein Ib. J Clin Invest 81:1734-40
Wise, R J; Pittman, D D; Handin, R I et al. (1988) The propeptide of von Willebrand factor independently mediates the assembly of von Willebrand multimers. Cell 52:229-36
Bockenstedt, P; Greenberg, J M; Handin, R I (1986) Structural basis of von Willebrand factor binding to platelet glycoprotein Ib and collagen. Effects of disulfide reduction and limited proteolysis of polymeric von Willebrand factor. J Clin Invest 77:743-9
Bockenstedt, P; McDonagh, J; Handin, R I (1986) Binding and covalent cross-linking of purified von Willebrand factor to native monomeric collagen. J Clin Invest 78:551-6

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