Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL043231-08
Application #
2220949
Study Section
Special Emphasis Panel (NSS)
Project Start
1989-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Chang, W; Pratt, S A; Chen, T H et al. (2001) Parathyroid cells express dihydropyridine-sensitive cation currents and L-type calcium channel subunits. Am J Physiol Endocrinol Metab 281:E180-9
Motoike, H K; Bodi, I; Nakayama, H et al. (1999) A region in IVS5 of the human cardiac L-type calcium channel is required for the use-dependent block by phenylalkylamines and benzothiazepines. J Biol Chem 274:9409-20
Varadi, G; Strobeck, M; Koch, S et al. (1999) Molecular elements of ion permeation and selectivity within calcium channels. Crit Rev Biochem Mol Biol 34:181-214
Mikala, G; Klockner, U; Varadi, M et al. (1998) cAMP-dependent phosphorylation sites and macroscopic activity of recombinant cardiac L-type calcium channels. Mol Cell Biochem 185:95-109
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He, M; Bodi, I; Mikala, G et al. (1997) Motif III S5 of L-type calcium channels is involved in the dihydropyridine binding site. A combined radioligand binding and electrophysiological study. J Biol Chem 272:2629-33
Bodi, I; Yamaguchi, H; Hara, M et al. (1997) Molecular studies on the voltage dependence of dihydropyridine action on L-type Ca2+ channels. Critical involvement of tyrosine residues in motif IIIS6 and IVS6. J Biol Chem 272:24952-60
Klockner, U; Mikala, G; Eisfeld, J et al. (1997) Properties of three COOH-terminal splice variants of a human cardiac L-type Ca2+-channel alpha1-subunit. Am J Physiol 272:H1372-81
Klockner, U; Mikala, G; Schwartz, A et al. (1996) Molecular studies of the asymmetric pore structure of the human cardiac voltage- dependent Ca2+ channel. Conserved residue, Glu-1086, regulates proton-dependent ion permeation. J Biol Chem 271:22293-6

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