Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL049234-12
Application #
6711760
Study Section
Special Emphasis Panel (NSS)
Program Officer
Link, Rebecca P
Project Start
1993-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
12
Fiscal Year
2004
Total Cost
$385,828
Indirect Cost

  Institution

Name
University of Illinois at Chicago
Department
Biochemistry
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Gettins, Peter G W; Olson, Steven T (2016) Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance. Biochem J 473:2273-93
Dementiev, Alexey; Swanson, Richard; Roth, Ryan et al. (2013) The allosteric mechanism of activation of antithrombin as an inhibitor of factor IXa and factor Xa: heparin-independent full activation through mutations adjacent to helix D. J Biol Chem 288:33611-9
Huang, Xin; Dementiev, Alexey; Olson, Steven T et al. (2010) Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa. J Biol Chem 285:20399-409
Gettins, Peter G W; Olson, Steven T (2009) Activation of antithrombin as a factor IXa and Xa inhibitor involves mitigation of repression rather than positive enhancement. FEBS Lett 583:3397-400
Gettins, Peter G W; Olson, Steven T (2009) Exosite determinants of serpin specificity. J Biol Chem 284:20441-5
Al-Ayyoubi, Maher; Schwartz, Bradford S; Gettins, Peter G W (2007) Maspin binds to urokinase-type and tissue-type plasminogen activator through exosite-exosite interactions. J Biol Chem 282:19502-9
Dobo, Jozsef; Gettins, Peter G W (2004) alpha1-Proteinase inhibitor forms initial non-covalent and final covalent complexes with elastase analogously to other serpin-proteinase pairs, suggesting a common mechanism of inhibition. J Biol Chem 279:9264-9
Backovic, Marija; Gettins, Peter G W (2002) Insight into residues critical for antithrombin function from analysis of an expanded database of sequences that includes frog, turtle, and ostrich antithrombins. J Proteome Res 1:367-73