Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL049907-13
Application #
6884611
Study Section
Special Emphasis Panel (NSS)
Program Officer
Lathrop, David A
Project Start
1993-05-01
Project End
2008-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
13
Fiscal Year
2005
Total Cost
$295,604
Indirect Cost
Name
Rockefeller University
Department
Physiology
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
Gadsby, David C; Takeuchi, Ayako; Artigas, Pablo et al. (2009) Review. Peering into an ATPase ion pump with single-channel recordings. Philos Trans R Soc Lond B Biol Sci 364:229-38
Gadsby, David C (2009) Ion channels versus ion pumps: the principal difference, in principle. Nat Rev Mol Cell Biol 10:344-52
Dousmanis, Athanasios G; Nairn, Angus C; Gadsby, David C (2002) Distinct Mg(2+)-dependent steps rate limit opening and closing of a single CFTR Cl(-) channel. J Gen Physiol 119:545-59
Csanady, L; Gadsby, D C (1999) CFTR channel gating: incremental progress in irreversible steps. J Gen Physiol 114:49-53
Gadsby, D C; Nairn, A C (1999) Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis. Physiol Rev 79:S77-S107
Gadsby, D C; Nairn, A C (1999) Regulation of CFTR Cl- ion channels by phosphorylation and dephosphorylation. Adv Second Messenger Phosphoprotein Res 33:79-106
Gadsby, D C; Dousmanis, A G; Nairn, A C (1998) ATP hydrolysis cycles and the gating of CFTR Cl- channels. Acta Physiol Scand Suppl 643:247-56
Senior, A E; Gadsby, D C (1997) ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR. Semin Cancer Biol 8:143-50
Gadsby, D C; Nagel, G; Hwang, T C (1995) The CFTR chloride channel of mammalian heart. Annu Rev Physiol 57:387-416
Hwang, T C; Nagel, G; Nairn, A C et al. (1994) Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis. Proc Natl Acad Sci U S A 91:4698-702

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