Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL071544-03
Application #
6831738
Study Section
Hematology Subcommittee 2 (HEM)
Program Officer
Hasan, Ahmed AK
Project Start
2003-01-01
Project End
2007-12-31
Budget Start
2005-01-01
Budget End
2005-12-31
Support Year
3
Fiscal Year
2005
Total Cost
$302,000
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pathology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Kroh, Heather K; Bock, Paul E (2012) Effect of zymogen domains and active site occupation on activation of prothrombin by von Willebrand factor-binding protein. J Biol Chem 287:39149-57
Kroh, Heather K; Panizzi, Peter; Tchaikovski, Svetlana et al. (2011) Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo. J Biol Chem 286:23345-56
Berny-Lang, M A; Aslan, J E; Tormoen, G W et al. (2011) Promotion of experimental thrombus formation by the procoagulant activity of breast cancer cells. Phys Biol 8:015014
Panizzi, Peter; Nahrendorf, Matthias; Figueiredo, Jose-Luiz et al. (2011) In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Nat Med 17:1142-6
Berny, Michelle A; Munnix, Imke C A; Auger, Jocelyn M et al. (2010) Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear. PLoS One 5:e10415
Kroh, Heather K; Panizzi, Peter; Bock, Paul E (2009) Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin. Proc Natl Acad Sci U S A 106:7786-91
Munnix, Imke C A; Kuijpers, Marijke J E; Auger, Jocelyn et al. (2007) Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation. Arterioscler Thromb Vasc Biol 27:2484-90
Friedrich, Rainer; Panizzi, Peter; Kawabata, Shun-Ichiro et al. (2006) Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation. J Biol Chem 281:1188-95
Panizzi, Peter; Friedrich, Rainer; Fuentes-Prior, Pablo et al. (2006) Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes. J Biol Chem 281:1179-87
Panizzi, Peter; Friedrich, Rainer; Fuentes-Prior, Pablo et al. (2006) Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions. J Biol Chem 281:1169-78

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