Nearly every form of cardiac disease involves changes to the myocardial stiffness. Current clinically-viable measurement techniques to assess myocardial stiffness are ei- ther invasive and/or involve image-derived metrics. We propose the use of a new imaging method, called Acoustic Radiation Force Impulse (ARFI) imaging, in measuring the me- chanical properties of myocardial tissue. The technique employs ultrasonic radiation force to displace tissue. Conventional ultrasound is then used to observe the response of the tissue to the force. We present preliminary data showing the success of this technique in imaging the changes in stiffness that occur under normal myocardial function. We pro- pose to further develop the ARFI imaging technique and then investigate the use of ARFI imaging in detecting abnormal heart function using animal models. In addition, we pro- pose human clinical studies with pediatric cardiac transplant patients. These studies will evaluate the potential of ARFI imaging to provide early detection of transplant rejection, in grading the severity of heart failure, and in distinguishing between systolic and diastolic heart failure.
Diseases of the heart often involve changes in the stiffness of the heart. We have developed a new imaging method that displays the stiffness of heart tissue. We propose animal and human studies to determine the potential of this method to reliably detect and predict cardiac diseases.
| Kakkad, Vaibhav; LeFevre, Melissa; Roy Choudhury, Kingshuk et al. (2018) Effect of Transmit Beamforming on Clutter Levels in Transthoracic Echocardiography. Ultrason Imaging 40:215-231 |
| Vejdani-Jahromi, Maryam; Freedman, Jenna; Kim, Young-Joong et al. (2018) Assessment of Diastolic Function Using Ultrasound Elastography. Ultrasound Med Biol 44:551-561 |
| Vejdani-Jahromi, Maryam; Freedman, Jenna; Nagle, Matthew et al. (2017) Quantifying Myocardial Contractility Changes Using Ultrasound-Based Shear Wave Elastography. J Am Soc Echocardiogr 30:90-96 |
| Jakovljevic, Marko; Bottenus, Nick; Kuo, Lily et al. (2017) Blocked Elements in 1-D and 2-D Arrays-Part II: Compensation Methods as Applied to Large Coherent Apertures. IEEE Trans Ultrason Ferroelectr Freq Control 64:922-936 |
| Heyde, Brecht; Bottenus, Nick; D'hooge, Jan et al. (2017) Evaluation of the Transverse Oscillation Technique for Cardiac Phased Array Imaging: A Theoretical Study. IEEE Trans Ultrason Ferroelectr Freq Control 64:320-334 |
| Jakovljevic, Marko; Pinton, Gianmarco F; Dahl, Jeremy J et al. (2017) Blocked Elements in 1-D and 2-D Arrays-Part I: Detection and Basic Compensation on Simulated and In Vivo Targets. IEEE Trans Ultrason Ferroelectr Freq Control 64:910-921 |
| Hollender, Peter; Kuo, Lily; Chen, Virginia et al. (2017) Scanned 3-D Intracardiac ARFI and SWEI for Imaging Radio-Frequency Ablation Lesions. IEEE Trans Ultrason Ferroelectr Freq Control 64:1034-1044 |
| Hollender, Peter; Lipman, Samantha L; Trahey, Gregg E (2017) Thee-Dimensional Single-Track-Location Shear Wave Elasticity Imaging. IEEE Trans Ultrason Ferroelectr Freq Control 64:1784-1794 |
| Vejdani-Jahromi, Maryam; Nagle, Mathew; Jiang, Yang et al. (2016) A Comparison of Acoustic Radiation Force-Derived Indices of Cardiac Function in the Langendorff Perfused Rabbit Heart. IEEE Trans Ultrason Ferroelectr Freq Control 63:1288-95 |
| Hollender, Peter; Bottenus, Nick; Trahey, Gregg (2015) A multiresolution approach to shear wave image reconstruction. IEEE Trans Ultrason Ferroelectr Freq Control 62:1429-39 |
Showing the most recent 10 out of 44 publications
