This longitudinal follow-up study of childhood-onset depressive disorders, currently in its 9th year, is entering a phase during which all Ss will have reached adolescence; it will thus be possible to observe the transition of a large subgroup of them into adulthood. Given the findings to date, the class of bipolar disorders is also being investigated. The study's developmental scope will be extended to include social competence and other areas of interest in late adolescence and young adulthood. Ss were 8-to-13 years old at intake. Recruitment is complete and includes 142 Ss with affective disorders and 49 age-matched comparisons with non-affective disorders. Drop-out rates have been low (11% for the affective-disorder Ss; 6% for the comparisons).
Specific aims i nclude contributions to nosology and developmental psychopathology, with a particular focus on the practical consequences of early-onset disorders. Nosologic goals entail the delineation of the long-term clinical course of childhood-onset depressive and bipolar disorders (e.g., recovery, chronicity, comorbidity); the predictive validity of these diagnoses; and the patterning of episodes and their associated features (including suicidal behaviors). In the sphere of developmental psychopathology, the developmental mediation of clinical course will be examined (e.g., transitions between juvenile and adult disorders, changes in comorbid conditions), and the effects of disorders on the progression of abilities (e.g., social competence, educational and vocational achievement). Other consequences will be examined in terms of rates of hospitalizations, institutionalizations, and incarcerations. A repeated-measures design will be used, with a comprehensive multiperspective assessment battery, including a semistructured psychiatric interview. Diagnoses will be based on the DSM-III. Ss will be evaluated biannually. Salient variables will be assessed independently of each other, and outcomes will be examined in the context of important covariates. This study is the first of its kind to follow children with affective disorders into their adulthood. Thereby, it will contribute to an improved nosology of these disorders a better understanding of the continuities and discontinuities between them and their """"""""adult"""""""" counterparts; and will shed further light on the developmental consequences of early-onset pathology, all of which have relevance to early-identification, prevention, and treatment or remediation of these conditions.
| Sherrill, Joel T; Kovacs, Maria (2004) Nonsomatic treatment of depression. Psychiatr Clin North Am 27:139-54, x |
| Kovacs, Maria; Obrosky, David Scott; Sherrill, Joel (2003) Developmental changes in the phenomenology of depression in girls compared to boys from childhood onward. J Affect Disord 74:33-48 |
| Sherrill, Joel T; Kovacs, Maria (2002) Nonsomatic treatment of depression. Child Adolesc Psychiatr Clin N Am 11:579-93 |
| Kovacs, M (2001) Gender and the course of major depressive disorder through adolescence in clinically referred youngsters. J Am Acad Child Adolesc Psychiatry 40:1079-85 |
| Vincent, J B; Neves-Pereira, M L; Paterson, A D et al. (2000) An unstable trinucleotide-repeat region on chromosome 13 implicated in spinocerebellar ataxia: a common expansion locus. Am J Hum Genet 66:819-29 |
| Vincent, J B; Yuan, Q P; Schalling, M et al. (2000) Long repeat tracts at SCA8 in major psychosis. Am J Med Genet 96:873-6 |
| Sherrill, J T; Kovacs, M (2000) Interview schedule for children and adolescents (ISCA). J Am Acad Child Adolesc Psychiatry 39:67-75 |
| Vincent, J B; Kovacs, M; Krol, R et al. (1999) Intergenerational CAG repeat expansion at ERDA1 in a family with childhood-onset depression, schizoaffective disorder, and recurrent major depression. Am J Med Genet 88:79-82 |
| Kovacs, M; Devlin, B (1998) Internalizing disorders in childhood. J Child Psychol Psychiatry 39:47-63 |
| Kovacs, M; Devlin, B; Pollock, M et al. (1997) A controlled family history study of childhood-onset depressive disorder. Arch Gen Psychiatry 54:613-23 |
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