Abstract

The long range goal of this research is to gain insight into the neural organization and mechanisms underlying motivation. It utilizes feeding behavior in Aplysia as a simplified model system. The current grant will investigate two issues: 1) What is the neural organization of a system that controls an appetitive, relatively nonstereotyped behavior such as orientation to food? 2) How is sensory input regulated during various motivational states? These questions could have relevance to both disorders of movement as well as of disorders of regulation of motivated behaviors (e.g., bulimia, obesity, and anorexia nervosa).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37MH035564-18
Application #
3486526
Study Section
Neurosciences Research Review Committee (BPN)
Project Start
1981-05-01
Project End
1994-04-30
Budget Start
1991-05-01
Budget End
1992-04-30
Support Year
18
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Vilim, Ferdinand S; Sasaki, Kosei; Rybak, Jurgen et al. (2010) Distinct mechanisms produce functionally complementary actions of neuropeptides that are structurally related but derived from different precursors. J Neurosci 30:131-47
Friedman, Allyson K; Zhurov, Yuriy; Ludwar, Bjoern Ch et al. (2009) Motor outputs in a multitasking network: relative contributions of inputs and experience-dependent network states. J Neurophysiol 102:3711-27
Sasaki, Kosei; Brezina, Vladimir; Weiss, Klaudiusz R et al. (2009) Distinct inhibitory neurons exert temporally specific control over activity of a motoneuron receiving concurrent excitation and inhibition. J Neurosci 29:11732-44
Jing, Jian; Gillette, Rhanor; Weiss, Klaudiusz R (2009) Evolving concepts of arousal: insights from simple model systems. Rev Neurosci 20:405-27
Sasaki, Kosei; Jing, Jian; Due, Michael R et al. (2008) An input-representing interneuron regulates spike timing and thereby phase switching in a motor network. J Neurosci 28:1916-28
Sasaki, Kosei; Due, Michael R; Jing, Jian et al. (2007) Feeding CPG in Aplysia directly controls two distinct outputs of a compartmentalized interneuron that functions as a CPG element. J Neurophysiol 98:3796-801
Romanova, Elena V; McKay, Natasha; Weiss, Klaudiusz R et al. (2007) Autonomic control network active in Aplysia during locomotion includes neurons that express splice variants of R15-neuropeptides. J Neurophysiol 97:481-91
Jing, Jian; Vilim, Ferdinand S; Horn, Charles C et al. (2007) From hunger to satiety: reconfiguration of a feeding network by Aplysia neuropeptide Y. J Neurosci 27:3490-502
Hurwitz, Itay; Susswein, Abraham J; Weiss, Klaudiusz R (2005) Transforming tonic firing into a rhythmic output in the Aplysia feeding system: presynaptic inhibition of a command-like neuron by a CpG element. J Neurophysiol 93:829-42
Proekt, Alex; Vilim, Ferdinand S; Alexeeva, Vera et al. (2005) Identification of a new neuropeptide precursor reveals a novel source of extrinsic modulation in the feeding system of Aplysia. J Neurosci 25:9637-48

Showing the most recent 10 out of 60 publications