Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
1R37MH042148-01A1
Application #
3486827
Study Section
Neurosciences Research Review Committee (BPN)
Project Start
1987-08-01
Project End
1991-07-31
Budget Start
1987-08-01
Budget End
1988-07-31
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Allegheny University of Health Sciences
Department
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129
Weiss, B; Davidkova, G; Zhou, L W (1999) Antisense RNA gene therapy for studying and modulating biological processes. Cell Mol Life Sci 55:334-58
Davidkova, G; Zhou, L W; Morabito, M et al. (1998) D2 dopamine antisense RNA expression vector, unlike haloperidol, produces long-term inhibition of D2 dopamine-mediated behaviors without causing Up-regulation of D2 dopamine receptors. J Pharmacol Exp Ther 285:1187-96
Weiss, B; Davidkova, G; Zhang, S P (1997) Antisense strategies in neurobiology. Neurochem Int 31:321-48
Weiss, B; Zhang, S P; Zhou, L W (1997) Antisense strategies in dopamine receptor pharmacology. Life Sci 60:433-55
Weiss, B; Davidkova, G; Zhou, L W et al. (1997) Expression of a D2 dopamine receptor antisense RNA in brain inhibits D2-mediated behaviors. Neurochem Int 31:571-80
Hadjiconstantinou, M; Neff, N H; Zhou, L W et al. (1996) D2 dopamine receptor antisense increases the activity and mRNA of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in mouse brain. Neurosci Lett 217:105-8
Zhou, L W; Zhang, S P; Weiss, B (1996) Intrastriatal administration of an oligodeoxynucleotide antisense to the D2 dopamine receptor mRNA inhibits D2 dopamine receptor-mediated behavior and D2 dopamine receptors in normal mice and in mice lesioned with 6-hydroxydopamine. Neurochem Int 29:583-95
Zhang, S P; Zhou, L W; Morabito, M et al. (1996) Uptake and distribution of fluorescein-labeled D2 dopamine receptor antisense oligodeoxynucleotide in mouse brain. J Mol Neurosci 7:13-28
Zhang, S P; Connell, T A; Price, T et al. (1995) Continuous infusion of clozapine increases mu and delta opioid receptors and proenkephalin mRNA in mouse brain. Biol Psychiatry 37:496-503
Qin, Z H; Zhou, L W; Zhang, S P et al. (1995) D2 dopamine receptor antisense oligodeoxynucleotide inhibits the synthesis of a functional pool of D2 dopamine receptors. Mol Pharmacol 48:730-7

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