The severity of behavioral abnormalities in schizophrenia has led many investigators to persist in search of neural dysfunction. Neuroimaging has provided unprecedented opportunities for a systematic examination of neural substrates for behavior and can be used as a powerful aid in understanding the pathophysiology of schizophrenia. The overall goal of this proposal is to relate neuroanatomic measures in schizophrenia to phenomenology and clinical course and to neurobehavioral functioning. We plan to obtain reliable measures of brain anatomy using MRI and perform volumetric analysis of regional brain structure and CSF. While neuroanatomic studies are important for improved understanding of normal and pathological brain function, their integration with clinical, neurobehavioral and physiologic data is essential for the study of regional brain function in schizophrenia. The proposed research will provide neuroanatomic measurements to which clinical data can be related. The neuroanatomic measures will be related to phenomenology and clinical course and to neurobehavioral deficits. It has been recognized that neuroanatomic abnormalities are unlikely to be the sole cause of brain dysfunction in schizophrenia, and physiologic abnormalities have been suggested. Magnetic resonance spectroscopy (MRS) can provide analytical qualitative and quantitative data on cellular metabolism and molecular structure. We will valuate the potential of MRS for measuring local metabolic parameters in schizophrenics and controls.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37MH042191-09
Application #
2245390
Study Section
Special Emphasis Panel (NSS)
Project Start
1987-01-01
Project End
1999-12-30
Budget Start
1995-02-01
Budget End
1995-12-31
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kuo, Susan S; Almasy, Laura; Gur, Ruben C et al. (2018) Cognition and community functioning in schizophrenia: The nature of the relationship. J Abnorm Psychol 127:216-227
Kos, Mark Z; Carless, Melanie A; Peralta, Juan et al. (2017) Exome sequences of multiplex, multigenerational families reveal schizophrenia risk loci with potential implications for neurocognitive performance. Am J Med Genet B Neuropsychiatr Genet 174:817-827
Kos, Mark Z; Carless, Melanie A; Peralta, Juan et al. (2016) Exome Sequence Data From Multigenerational Families Implicate AMPA Receptor Trafficking in Neurocognitive Impairment and Schizophrenia Risk. Schizophr Bull 42:288-300
Thomas, Pramod; Bhatia, Triptish; Gauba, Deepak et al. (2013) Exposure to herpes simplex virus, type 1 and reduced cognitive function. J Psychiatr Res 47:1680-5
Yokley, Jessica L; Prasad, Konasale M; Chowdari, Kodavali V et al. (2012) Genetic associations between neuregulin-1 SNPs and neurocognitive function in multigenerational, multiplex schizophrenia families. Psychiatr Genet 22:70-81
Tarbox, Sarah I; Almasy, Laura; Gur, Raquel E et al. (2012) The nature of schizotypy among multigenerational multiplex schizophrenia families. J Abnorm Psychol 121:396-406
Drago, Antonio; Giegling, Ina; Schäfer, Martin et al. (2012) No association of a set of candidate genes on haloperidol side effects. PLoS One 7:e44853
Moberg, Paul J; Li, Mingyao; Kanes, Stephen J et al. (2012) Association of schizophrenia with the phenylthiocarbamide taste receptor haplotype on chromosome 7q. Psychiatr Genet 22:286-9
Prasad, Konasale M; Almasy, Laura; Gur, Ruben C et al. (2010) RGS4 polymorphisms associated with variability of cognitive performance in a family-based schizophrenia sample. Schizophr Bull 36:983-90
Dickinson, Dwight; Ragland, J Daniel; Gold, James M et al. (2008) General and specific cognitive deficits in schizophrenia: Goliath defeats David? Biol Psychiatry 64:823-7

Showing the most recent 10 out of 68 publications