Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37MH044346-09
Application #
2246092
Study Section
Special Emphasis Panel (NSS)
Project Start
1988-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Tallent, Melanie K; Fabre, Veronique; Qiu, Cuie et al. (2005) Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning. Mol Cell Neurosci 30:465-75
Schweitzer, Paul; Madamba, Samuel G; Siggins, George R (2003) The sleep-modulating peptide cortistatin augments the h-current in hippocampal neurons. J Neurosci 23:10884-91
Krucker, Thomas; Siggins, George R; McNamara, Robert K et al. (2002) Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus. J Neurosci 22:5525-35
Baratta, Michael V; Lamp, Tyra; Tallent, Melanie K (2002) Somatostatin depresses long-term potentiation and Ca2+ signaling in mouse dentate gyrus. J Neurophysiol 88:3078-86
Sanna, P P; Berton, F; Cammalleri, M et al. (2000) A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus. Proc Natl Acad Sci U S A 97:8653-7
Schweitzer, P; Siggins, G R; Madamba, S G (1999) Cannabinoid modulation of neuronal activity in adult rat hippocampus. Adv Exp Med Biol 469:547-52
Madamba, S G; Schweitzer, P; Siggins, G R (1999) Dynorphin selectively augments the M-current in hippocampal CA1 neurons by an opiate receptor mechanism. J Neurophysiol 82:1768-75
Madamba, S G; Schweitzer, P; Siggins, G R (1999) Nociceptin augments K(+) currents in hippocampal CA1 neurons by both ORL-1 and opiate receptor mechanisms. J Neurophysiol 82:1776-85
Schweitzer, P; Madamba, S G; Siggins, G R (1998) Somatostatin increases a voltage-insensitive K+ conductance in rat CA1 hippocampal neurons. J Neurophysiol 79:1230-8
Tallent, M K; Siggins, G R (1997) Somatostatin depresses excitatory but not inhibitory neurotransmission in rat CA1 hippocampus. J Neurophysiol 78:3008-18

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