This supplement request describes the research and training plan for an underrepresented candidate with background in organic chemistry and an aspiration to become an independent investigator in antimicrobial resistance. The candidate will learn novel chemistries, chemical biology, biophysical techniques, with emphasis on antimicrobial synthesis, development and efficacy determination to identify novel rRNA binding antibacterial therapeutics. The success of the proposed work would be a significant addition to currently available approaches in antibacterial therapy and train a promising candidate in biomedical sciences.

Public Health Relevance

The proposed project presents a mentoring and training strategy in the development of novel antimicrobials with novel rRNA discriminating recognition oligomers. Antimicrobial resistance occurs when microorganisms (often infectious bacteria, viruses, and certain parasites) are no longer sensitive to drugs that were previously used to treat them; this is of global concern because it hampers our ability to control infectious disease and increases the costs of health care. In order to combat this world-wide problem, innovative strategies for antibiotic drug design must be implemented. The proposed research describes such a mentoring and training plan using novel antimicrobial compounds that evade common resistance pathways.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Small Business Technology Transfer (STTR) Grants - Phase I (R41)
Project #
3R41AI152613-01S2
Application #
10123062
Study Section
Program Officer
Xu, Zuoyu
Project Start
2020-03-07
Project End
2022-02-28
Budget Start
2021-02-05
Budget End
2021-02-28
Support Year
1
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Nubad, LLC
Department
Type
DUNS #
831389122
City
Greenville
State
SC
Country
United States
Zip Code
29605