Multiple sclerosis (MS) is a neurodegenerative disease in which myelin of the central nervous system (CNS) is destroyed by a self-reactive immune response. This demyelination is accompanied by the death of the myelinating cells themselves, the oligodendrocytes. Repeated bouts of demyelination leave the denuded CNS neurons vulnerable to degradation and is the major cause of neuronal dysfunction and neurodegeneration in MS. Current approved therapies for MS are aimed only at lessening the frequency of the auto-immune attack and do not address the need for remyelination. Without induction of remyelination to heal previous lesions, the course of disease can only be slowed but not reversed. The CNS contains a large population of oligodendrocyte precursor cells (OPC) that have the potential to differentiate into mature oligodendrocytes and remyelinate denuded axons. Although OPCs are efficiently recruited into MS lesions, OPC differentiation into mature oligodendrocytes, and subsequent remyelination, is inhibited in MS. Novoron has discovered that the LRP1 receptor is a key signaling molecule that prevents OPC differentiation. By abrogating LRP1 function using either genetic deletion or antagonism, we can increase OPC differentiation and restore the remyelinating capacity of the brain. The goal of this proposal is to transition from our preliminary data demonstrating our novel approach to remyelination to developing this technology into a viable human drug. By the end of this Phase 1 application, Novoron will possess the following: 1) a lead drug candidate with an in vivo dose-response profile, 2) disease efficacy data in the cuprizone chemical demyelinating model, and 3) disease efficacy data in the autoimmune- mediated EAE MS model. These data will demonstrate the feasibility of our approach to healing MS leasions and preapre Novoron for an efficient comercialization-focused Phase 2 application.

Public Health Relevance

Disability and death in multiple sclerosis result from neuronal damage that arises from demyelination. Oligodendrocyte progenitor cells (OPCs) have the ability to infiltrate areas of demylination and remyelinate denuded axons, thereby preventing neuronal damage and reversing disability, but their differentiation into mature myelinating oligodendrocytes is inhibited by debris within the lesion site. The goal of this project is to further characterize and develop our lead molecule with the objective of creating the first therapeutic to overcome the suppression of OPC differentiation and restore myelination thereby overcoming the functional deficits that result from neuronal damage and loss.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Small Business Technology Transfer (STTR) Grants - Phase I (R41)
Project #
1R41NS110159-01A1
Application #
9778488
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Trzcinski, Natalie Katherine
Project Start
2019-09-15
Project End
2021-05-31
Budget Start
2019-09-15
Budget End
2020-05-31
Support Year
1
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Novoron Bioscience, Inc.
Department
Type
DUNS #
078781043
City
San Diego
State
CA
Country
United States
Zip Code
92122