application): The goal of this project is to validate a new method for drug-lead discovery that relies on cascaded multi-step selection of small chemical groups to construct larger molecules having high affinity for a protein target. This method increases efficiency over combinatorial chemistry in executing the selection before, rather than after, chemical synthesis. This technology will be developed using thymidylate synthase, a validated target for anti-cancer and anti-proliferative agents.
NOT AVAILABLE
| Erlanson, D A; Braisted, A C; Raphael, D R et al. (2000) Site-directed ligand discovery. Proc Natl Acad Sci U S A 97:9367-72 |
