To date, chimeric chickens are made by injecting blastodermal cells or embryonic stem cells into the stage X embryo (recipient), but the frequency and the level of chimerism is variable and unpredictable. We plan to develop a universal recipient that contributes minimally, so that the contribution of donor derived cells to the resulting chimera is constantly high and predictable. Somatic chimeras can be used to produce biopharmaceutical proteins in eggs as soon as the chimeras commence laying and before they transmit the gene encoding the biopharmaceutical protein to the next generation.

Proposed Commercial Applications

NOT AVAILABLE

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43GM064096-01
Application #
6403315
Study Section
Special Emphasis Panel (ZRG1-BCE (10))
Program Officer
Wolfe, Paul B
Project Start
2001-09-01
Project End
2002-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
1
Fiscal Year
2001
Total Cost
$100,000
Indirect Cost
Name
Origen Therapeutics
Department
Type
DUNS #
026167994
City
Emeryville
State
CA
Country
United States
Zip Code
94608