Approximately 190,000 new cases of prostate cancer will be diagnosed in the U.S. in 2003, and this year 30,400 American men will die from prostate cancer. In the United States, the annual cost of treating prostate cancer has reached $1.72 billion. While there are a significant number of potential courses for treating prostate cancer, a single """"""""best treatment"""""""" has not yet emerged, especially for managing early prostate cancer. Many current therapies have significant attendant side effects and/or risks associated with them. For this reason, continued effort has been expended toward development of minimally invasive means of targeting early-localized prostate cancer. In this Phase II SBIR application, we propose to develop and test a system for magnetic resonance imaging (MRI) guided laser ablation of localized prostate cancer. The system will use multiple interstitial laser delivery probes to effect targeted treatment volumes in the prostate. A laser/computer workstation precisely controls the deposition of laser energy based on processing of real-time temperature sensitive MR images acquired during therapy. An advanced Visualization and control interface will allow the user to specify and update therapeutic targets during treatment. This system will be tested in a canine tumor model of prostate cancer. Based on our prior experience, we believe that this system will offer an improvement in treatment of prostate cancer through minimally invasiveness, improved targeting accuracy, and feedback of real-time information about treatment progression.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44AG019276-03
Application #
6791122
Study Section
Special Emphasis Panel (ZRG1-RTB (11))
Program Officer
Yancik, Rosemary
Project Start
2000-09-15
Project End
2006-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
3
Fiscal Year
2004
Total Cost
$264,742
Indirect Cost
Name
Biotex, Inc.
Department
Type
DUNS #
969792050
City
Houston
State
TX
Country
United States
Zip Code
77054
Stafford, R Jason; Shetty, Anil; Elliott, Andrew M et al. (2010) Magnetic resonance guided, focal laser induced interstitial thermal therapy in a canine prostate model. J Urol 184:1514-20
Carpentier, Alexandre; McNichols, Roger J; Stafford, R Jason et al. (2008) Real-time magnetic resonance-guided laser thermal therapy for focal metastatic brain tumors. Neurosurgery 63:ONS21-8;discussion ONS28-9