The proposal outlines the development of a metaphoric process to convert mouse monoclonal antibodies (MAbs) to human MAbs using molecular biology techniques. Murine MAbs are being used in many clinical applications such as cancer, septic shock and transplantation. The use of human MAb would obviate the human anti-mouse MAb response which often blunts the clinical usefulness of mouse MAb in immunotherapy. However, for most indications human MAb are very difficult or impossible to obtain against human antigens. By the application of the metaphoric process human MAbs could be cloned that have the same binding affinity as mouse MAbs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44AI032822-02A1
Application #
2067710
Study Section
Special Emphasis Panel (ZRG7-SSS-4 (02))
Project Start
1992-06-01
Project End
1997-04-30
Budget Start
1995-05-01
Budget End
1996-04-30
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Tera Biotechnology Corporation
Department
Type
DUNS #
959329814
City
San Diego
State
CA
Country
United States
Zip Code
92109