Synthesis of New Antihiv Agents Related to Calanolide A

Flavin, Michael T.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Small Business Innovation Research Grants (SBIR) - Phase II (R44)
• Project #: 5R44AI034805-03
• Application #: 2069988
• Study Section: Medicinal Chemistry Study Section (MCHA)
• Project Start: 1993-08-15
• Project End: 1997-03-31
• Budget Start: 1996-04-01
• Budget End: 1997-03-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: Medichem Research, Inc.
• City: Lemont
• State: IL
• Country: United States
• Zip Code: 60439

Publications

Zembower, D E; Liao, S; Flavin, M T et al. (1997) Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C). J Med Chem 40:1005-17

Flavin, M T; Rizzo, J D; Khilevich, A et al. (1996) Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+/-)-calanolide A and its enantiomers. J Med Chem 39:1303-13