This is a new, fast track application that explains the need for additional therapeutics for the treatment of chronic hepatitis B virus (HBV) infection. Discovery of novel non cytotoxic L-nucleosides with potent anti-HBV activity that, when used in combination, act synergistically is described. These L-nucleosides are reported to inhibit the viral DNA polymerase and replication without effect upon cellular polymerases or mitocohndrial function and have been shown to significantly reduce viral load in the chronic woodchuck hepatitis model. Funding from SBIR phase 1 and 2 will be used to select and develop the combination of the L-nucleosides with the greatest potential for commercialization. Phase 1 will determine pharmacology, toxicology and antiviral potency of two and three L nucleoside combinations in the woodchuck chronic hepatitis model.

Proposed Commercial Applications

Chronic treatment of Hepatitis B virus infection. Delay in progression to cirrhosis and hepatocellular carcinoma. Possible elimination of Hepatitis B virus.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
1R44AI047784-01
Application #
6143568
Study Section
Special Emphasis Panel (ZRG1-SSS-K (01))
Program Officer
Johnson, Leslye D
Project Start
2000-07-15
Project End
2001-01-15
Budget Start
2000-07-15
Budget End
2001-01-15
Support Year
1
Fiscal Year
2000
Total Cost
$100,000
Indirect Cost
Name
Idenix Pharmaceuticals
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02144