Present treatment of Rheumatoid Arthritis is performed by several methods which include anti-inflammatory agents, steroids, immunosuppressive and cytotoxic agents, radiation treatment by beam method, and surgery. Each method has its drawbacks. Of these methods, radiation beam treatment has been shown to suppress the inflamed synovium and palliate the patient's pain. There are, however, adverse effects to surrounding hard and soft tissue. The objective of this proposed work is to use a glass matrix containing an activatable beta emitting isotope with a treatment distance of 1 to 3 mm. When injected into the joint, the microspheres will permit a localized irradiation of the diseased area leading to results comparable to that provided by surgery. Once the radioactivity has decayed, the microspheres will dissolve and absorbed into the body over a 3 to 6 month time period.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44AR040631-02A1
Application #
2080175
Study Section
Special Emphasis Panel (ZRG7-SSS-1 (03))
Project Start
1990-07-05
Project End
1995-08-31
Budget Start
1993-09-01
Budget End
1994-08-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
MO-Sci Corporation
Department
Type
DUNS #
City
Rolla
State
MO
Country
United States
Zip Code
65401