Complement protein Factor D plays an important role in the alternative pathway of the complement system. Inhibitors for Factor D have potential application in treatment of adult respiratory syndrome (ARDS) and autoimmune diseases such as rheumatoid arthritis. The phase I aim of this proposal was to determine three-dimensional structure of Factor by X-ray crystallographic methods. We have determined the three-dimensional structure by a combination of molecular replacement model and multiple isomorphous replacement methods. The structure has been refined to 2 Angstrom resolution. The objective of the work described in this proposal is to design and synthesize specific inhibitors for Factor D using a structure-based drug design process.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44AR041095-02
Application #
2080466
Study Section
Special Emphasis Panel (ZRG7-SSS-6 (06))
Project Start
1994-02-16
Project End
1996-02-15
Budget Start
1994-02-16
Budget End
1995-02-15
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Biocryst Pharmaceuticals, Inc.
Department
Type
DUNS #
City
Birmingham
State
AL
Country
United States
Zip Code