The objective is to produce a compact system to quantify body fluids by spectral (color) absorbance using test tubes coated with antibodies generated by immunogens we designed to identify specific moities. Marker preparation follows the same rationale. The tactical plan includes enzyme immunoassay (EIA) panel expansion, EIA simplification, EIA of multiple drugs simultaneously and EIA by novel format in which (drug) concentration is directly related to intensity of absorbance. The system is portable but matches the sensitivity and reliability of the best reference laboratory RIA. Its programmed reader, printer, IgG-coated tubes and reagents will be sent to consumers in one simple briefcase. The emergency room (ER) will have an immediate laboratory answer around the clock. A nanogram/m1 drug profile of urine, blood or both can be entered into the records before the patient leaves the site. Urine and blood analyses performed at the same time do not replace GC MS which is always advised for confirmation and definitive diagnosis, but they do aid a presumptive diagnosis and therapy in a hospital milieu.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44DA006345-02A1
Application #
2118661
Study Section
Special Emphasis Panel (SRCD (15))
Project Start
1992-09-05
Project End
1994-08-31
Budget Start
1992-09-05
Budget End
1993-08-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Immunalysis Corporation
Department
Type
DUNS #
City
San Dimas
State
CA
Country
United States
Zip Code
91773