Abstract

This project focuses upon C.A.S.A. (computer aided sperm analysis) technology for analysis of sperm motion. In the Phase II project, the technological accomplishments of the prototype system tested in Phase I will, with certain innovations, be upgraded into a clinical instrument (Specific Aim 1) which will be validated (Specific Aim 2) and clinically tested (Specific Aim 3). Innovations for Phase II include: a method for optimization of phase contrast optics for human sperm, addition of strobed fluorescent capability to the internal optical system developed in Phase I, and rapid electronic alternation of strobed fluorescent and phase contrast illuminations. Software for this system will have the flexibility to produce data consistent with evolving W.H.O. and C.A.P. guidelines. The instrument will substantially increase both the range of tests accessible to automated semen analysis and the corresponding commercial opportunities for the end product.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44ES005620-02
Application #
3507575
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1990-09-28
Project End
1994-03-31
Budget Start
1992-04-01
Budget End
1993-03-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Hamilton-Thorn Research, Inc.
Department
Type
DUNS #
City
Danvers
State
MA
Country
United States
Zip Code
01923