verbatim): The long-term goal of this project is to provide radiation therapy departments and equipment vendors with a unique tool for accurate, fast and fully three-dimensional characterization of small radiotherapy fields, whether external beams or brachytherapy, with isotropic spatial resolution on the order of 100 microns. Our system is based on laser micro-beam CT scanning of tissue-equivalent dosimeter gels that change their optical properties in proportion to the absorbed dose. In Phase I we have designed, built and thoroughly tested two different prototypes of the micro-scanner, and have successfully proved the feasibility of our idea. In Phase II we will complete the research and development of the micro-scanner and will engineer various gel phantoms for micro-scanning. We will field-test our system in a clinical environment, and perform thorough dosimetry studies of various small fields and brachytherapy sources of clinical importance, comparing our technique with radiochromic film measurements. In Phase III we will license out the manufacture of our micro-scanner, and concentrate our efforts on manufacturing various gel dosimetry phantoms for high-resolution 3D dosimetry. We believe that our system will find widespread use in QA procedures and in patient treatment verification, wherever very high dose gradients are present in the treatment plan.

Proposed Commercial Applications

Not Available

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44HL059813-02A2
Application #
6298637
Study Section
Special Emphasis Panel (ZRG1-SSS-7 (87))
Program Officer
Dunn, Rosalie
Project Start
2001-03-15
Project End
2003-02-28
Budget Start
2001-03-15
Budget End
2002-02-28
Support Year
2
Fiscal Year
2001
Total Cost
$588,244
Indirect Cost
Name
Mgs Research, Inc.
Department
Type
DUNS #
837819226
City
Madison
State
CT
Country
United States
Zip Code
06443
Xu, Y; Wuu, Cheng-Shie; Maryanski, Marek J (2010) Sensitivity calibration procedures in optical-CT scanning of BANG 3 polymer gel dosimeters. Med Phys 37:861-8
Adamovics, J; Maryanski, M J (2006) Characterisation of PRESAGE: A new 3-D radiochromic solid polymer dosemeter for ionising radiation. Radiat Prot Dosimetry 120:107-12
Wuu, Cheng-Shie; Xu, Y (2006) Three-dimensional dose verification for intensity modulated radiation therapy using optical CT based polymer gel dosimetry. Med Phys 33:1412-9
Xu, Y; Wuu, Cheng-Shie; Maryanski, Marek J (2004) Performance of a commercial optical CT scanner and polymer gel dosimeters for 3-D dose verification. Med Phys 31:3024-33
Xua, Y; Wuu, Cheng-Shie; Maryanski, Marek J (2003) Determining optimal gel sensitivity in optical CT scanning of gel dosimeters. Med Phys 30:2257-63