The purpose of the proposed study is to develop a method for highly selective injury to pain sensitive neurons within the DRG. Phase I results showed a positive accumulation of a photocytotoxic dye encapsulated in latex nanosphere particles in the DRG. Pulsed and CW laser radiation effected selective, dose-dependent injury to small diameter neurons in the absence of non-specific injury to all control groups. The experiments successfully completed in Phase I will be refined and expanded in mice and rats to confirm histologically and optimize the choice of laser parameters. Sensory and motor neurophysiologic effects will be investigated in larger animals using behavioral assessment and sophisticated near-nerve potential and microneurography techniques. A prototype laser/fiber optic delivery system will be developed and refined for this application. The intent in Phase II is to set the stage for pre-clinical investigations in primates and clinical trials in Phase III. This technology would offer a therapy for intractable pain syndromes associated with malignancy, metabolic neuropathies, and peripheral nervous system trauma.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44NS028279-03
Application #
3509275
Study Section
Special Emphasis Panel (SSS (B1))
Project Start
1989-09-25
Project End
1994-04-30
Budget Start
1992-05-01
Budget End
1994-04-30
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Candela Corporation
Department
Type
DUNS #
City
Wayland
State
MA
Country
United States
Zip Code
01778