The long-range goal of this project is to develop a clinical method to enhance peripheral nerve regeneration utilizing electromagnetic fields (EMF). To design a signal that promotes the optimal response in regeneration of peripheral nerves, the applicants will perform both in vitro and in vivo experiments in Phase II of this project. The results of Phase I in vitro studies on a chick embryo dorsal root ganglia (DRG) are encouraging. The applicants were able to obtain a significant increase in the neurite length with one out of three electromagnetic fields tested. In Phase II, they will continue to optimize the electrical parameters in vitro and follow with the functional studies in an animal model. If successful, the project will lead to performing clinical trials after completion of the Phase II.

Proposed Commercial Applications

NOT AVAILABLE

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44NS033033-04
Application #
6529467
Study Section
Special Emphasis Panel (ZRG1-SSS-X (16))
Program Officer
Kleitman, Naomi
Project Start
1996-02-01
Project End
2003-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
4
Fiscal Year
2002
Total Cost
$514,835
Indirect Cost
Name
Herbst Research, Inc.
Department
Type
DUNS #
026260377
City
Edgewater
State
NJ
Country
United States
Zip Code
07020
Walker, Janet L; Kryscio, Richard; Smith, Jennifer et al. (2007) Electromagnetic field treatment of nerve crush injury in a rat model: effect of signal configuration on functional recovery. Bioelectromagnetics 28:256-63