Stroke can now be treated. As new interventions are introduced for cerebral thrombosis and embolism, emergency stroke evaluation requires rapid assessment of ischemic brain damage Studies with both animal models and human neurosurgical monitoring have shown that the EEG provides an immediate reflection of cortical ischemia. In this Phase I project, we will determine the feasibility of acquiring dense array EEG with stroke patients in the hospital setting. We will then determine whether there is significant improvement in stroke localization with the 128-channel EEG compared to conventional 19-channel EEG. Localization of the ischemic lesion is integral to detecting a stroke with the EEG, because focal slowing can be differentiated from diffuse slowing due to other cerebral pathology. Even with advanced methods, EEG localization of a completed infarction will be inferior to that from MRI. Furthermore, CT may continue to be required for detecting hemorrhagic stroke. However, if we can improve localization with dense array EEG methods, we can improve the emergency detection of stroke, and thus optimize the excellent temporal resolution of the EEG in characterizing the dynamic time course of the pathophysiology of ongoing cerebral ischemia.

Proposed Commercial Applications

NOT AVAILABLE

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44NS038829-03
Application #
6394154
Study Section
Special Emphasis Panel (ZRG1-BDCN-1 (06))
Program Officer
Marler, John R
Project Start
1999-08-01
Project End
2003-05-31
Budget Start
2001-06-01
Budget End
2003-05-31
Support Year
3
Fiscal Year
2001
Total Cost
$535,361
Indirect Cost
Name
Electrical Geodesics, Inc.
Department
Type
DUNS #
809845365
City
Eugene
State
OR
Country
United States
Zip Code
97403
Ferree, T C; Hwa, R C (2005) Electrophysiological measures of acute cerebral ischaemia. Phys Med Biol 50:3927-39
Hwa, Rudolph C; He, Wei; Ferree, Thomas C (2003) The global effects of stroke on the human electroencephalogram. J Integr Neurosci 2:45-53
Clay, M T; Ferree, T C (2002) Weighted regularization in electrical impedance tomography with applications to acute cerebral stroke. IEEE Trans Med Imaging 21:629-37
Hwa, Rudolph C; Ferree, Thomas C (2002) Scaling properties of fluctuations in the human electroencephalogram. Phys Rev E Stat Nonlin Soft Matter Phys 66:021901
Ferree, T C; Luu, P; Russell, G S et al. (2001) Scalp electrode impedance, infection risk, and EEG data quality. Clin Neurophysiol 112:536-44
Luu, P; Tucker, D M; Englander, R et al. (2001) Localizing acute stroke-related EEG changes: assessing the effects of spatial undersampling. J Clin Neurophysiol 18:302-17