Abstract

In Phase I, the proposal aims to develop a product prototype of an incremental scanning image cytometer previously demonstrated at UCSD. In addition to instrument hardware, to be either obtained """"""""off-the-shelf"""""""" or specially manufactured for Q3DM, the investigators will also develop software to support the image cytometer. In Phase II, the proposal aims to develop a new type of image cytometer based on continuous scanning. Phase II will culminate in shipping versions of the continuous scanning and the incremental scanning image cytometers. In addition, cell-classification tools will be developed and a multi-color fluorescence capability will be added.

Proposed Commercial Applications

NOT AVAILABLE

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44RR015170-03
Application #
6683338
Study Section
Special Emphasis Panel (ZRG1-SSS-I (01))
Program Officer
Swain, Amy L
Project Start
2001-05-01
Project End
2005-04-30
Budget Start
2003-02-01
Budget End
2005-04-30
Support Year
3
Fiscal Year
2003
Total Cost
$667,526
Indirect Cost

  Institution

Name
Vala Sciences, Inc.
Department
Type
DUNS #
612181532
City
San Diego
State
CA
Country
United States
Zip Code
92121

  Publications

Prigozhina, Natalie L; Zhong, Ling; Hunter, Edward A et al. (2007) Plasma membrane assays and three-compartment image cytometry for high content screening. Assay Drug Dev Technol 5:29-48
Morelock, Maurice M; Hunter, Edward A; Moran, Timothy J et al. (2005) Statistics of assay validation in high throughput cell imaging of nuclear factor kappaB nuclear translocation. Assay Drug Dev Technol 3:483-99
Price, Jeffrey H; Goodacre, Angela; Hahn, Klaus et al. (2002) Advances in molecular labeling, high throughput imaging and machine intelligence portend powerful functional cellular biochemistry tools. J Cell Biochem Suppl 39:194-210