This application proposes to design and implement a series of simulation studies and secondary data analyses to compare different design and analysis approaches to sequential decision making in the context of alcohol treatment. In this proposal, we focus on selection of treatment regimes, using Bayesian and causal models. Our goal is to demonstrate that these approaches can be understood and implemented by clinical researchers.

Public Health Relevance

This application proposes to design and implement a series of simulation studies and secondary data analyses to compare different design and analysis approaches to sequential decision making in the context of alcohol treatment. In this proposal, we focus on selection of treatment regimes, using Bayesian and causal models. Our goal is to demonstrate that these approaches can be understood and implemented by clinical researchers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
NIH Challenge Grants and Partnerships Program (RC1)
Project #
1RC1AA019092-01
Application #
7821074
Study Section
Special Emphasis Panel (ZRG1-HDM-P (58))
Program Officer
Falk, Daniel
Project Start
2009-09-25
Project End
2011-08-31
Budget Start
2009-09-25
Budget End
2010-08-31
Support Year
1
Fiscal Year
2009
Total Cost
$247,563
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Lu, Xi; Nahum-Shani, Inbal; Kasari, Connie et al. (2016) Comparing dynamic treatment regimes using repeated-measures outcomes: modeling considerations in SMART studies. Stat Med 35:1595-615
Lu, Xi; Lynch, Kevin G; Oslin, David W et al. (2016) Comparing treatment policies with assistance from the structural nested mean model. Biometrics 72:10-9
Ertefaie, Ashkan; Wu, Tianshuang; Lynch, Kevin G et al. (2016) Identifying a set that contains the best dynamic treatment regimes. Biostatistics 17:135-48
Lei, H; Nahum-Shani, I; Lynch, K et al. (2012) A ""SMART"" design for building individualized treatment sequences. Annu Rev Clin Psychol 8:21-48