This proposal requests an x-ray diffractometer and associated data system for crystal structure solution and refinement to serve the needs of a group of researchers in the Yale Chemistry Department involved in NIH-sponsored research in chemical synthesis. This system is to be optimized for determination of the structures of small organic molecules, the intermediates and synthetic targets in the research programs of the investigators. These projects involve synthesis and characterization of a wide range of molecules of biological importance, including macrolides, vitamins, tetramic acids, lactam antibiotics, carbohydrates, steroids, alkoloids and other natural products. The proposed instrument will be placed in the Yale Chemical Instrumentation Center, where a staff crystallographer will maintain and operate the diffractometer and provide crystal structure determination services to the investigators.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Unknown (S03)
Project #
2S03RR003406-07
Application #
3512374
Study Section
Special Emphasis Panel (NSS)
Project Start
1985-03-01
Project End
1992-02-29
Budget Start
1991-03-01
Budget End
1992-02-29
Support Year
7
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Lawrence Livermore National Laboratory
Department
Type
Organized Research Units
DUNS #
827171463
City
Livermore
State
CA
Country
United States
Zip Code
94550