It has been well-documented that peripheral glucose administration enhances memory in both young and old rodents and humans. It has also been shown that aged rats receive more benefit from epinephrine administration shortly after a learning episode than do non-aged adult rats. The general purpose of the proposed research is to determine if the effects of glucose on recently reactivated memories are related to age in a developmental sequence. A combination of different designs will be used to test the general hypotheses that: a) aged subjects receive significantly more benefit from a reminder cue (reactivation) than do younger adult subjects, and b) while greater memory enhancement may be produced by glucose in younger subjects than in older subjects, the actual benefit received from glucose administration increases as subjects age. The main experimentation will involve a combination of longitudinal and cross-sectional designs. In the longitudinal part of the design 3, 6, 9, 12, 15, 18, 21, and 24-month old rats will be injected with either glucose or saline after a reactivation treatment. In the cross-sectional part of the design, cohort groups of rats matched for age will be treated in a manner similar to those in the longitudinal part of the design. A passive avoidance-to-active avoidance negative transfer design will be used to measure the ways in which memory reactivation and glucose modulate the memories of rats during various stages of the lifespan. Because in the memory impaired (e.g., aged and Alzheimer's patients) glucose enhances memory, and because reactivation treatments affect both infant memory and adult emotional memory, the proposed studies may have both practical and clinical significance.

Project Start
1998-08-01
Project End
1999-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
27
Fiscal Year
1998
Total Cost
Indirect Cost
Name
New Mexico Highlands University
Department
Type
DUNS #
City
Las Vegas
State
NM
Country
United States
Zip Code
87701
Nesterova, Svitlana V; Wiedenfeld, David J; Nesterov, Vladimir N (2004) 5-Acetyl-2-amino-6-methyl-4-(1-naphthyl)-4H-pyran-3-carbonitrile, methyl 6-amino-5-cyano-2-methyl-4-(1-naphthyl)-4H-pyran-3-carboxylate and tert-butyl 6-amino-5-cyano-2-methyl-4-(1-naphthyl)-4H-pyran-3-carboxylate. Acta Crystallogr C 60:o559-63
Wiedenfeld, David J; Nesterov, Vladimir N; Minton, Mark A et al. (2004) 1-Chloro-3,6-dimethoxy-2,5-dimethylbenzene and 1-chloro-3,6-dimethoxy-2,4-dimethylbenzene. Acta Crystallogr C 60:o536-8
Wiedenfeld, David J; Nesterov, Vladimir N; Minton, Mark A et al. (2003) Bis(2,5-dimethoxy-4-methylphenyl)methane and bis(2,5-dimethoxy-3,4,6-trimethylphenyl)methane. Acta Crystallogr C 59:o700-2
Masthay, Mark B; Sammeth, David M; Helvenston, Merritt C et al. (2002) The laser-induced blue state of bacteriorhodopsin: mechanistic and color regulatory roles of protein-protein interactions, protein-lipid interactions, and metal ions. J Am Chem Soc 124:3418-30
Hayward, W A; Fritz, K R; Greene, E R (2000) Human middle cerebral artery blood velocity during sexual intercourse. J Ultrasound Med 19:871-6
Rodriguez, W A; Horne, C A; Mondragon, A N et al. (1994) Comparable dose-response functions for the effects of glucose and fructose on memory. Behav Neural Biol 61:162-9
Serrano, P A; Beniston, D S; Oxonian, M G et al. (1994) Differential effects of protein kinase inhibitors and activators on memory formation in the 2-day-old chick. Behav Neural Biol 61:60-72
Rodriguez, W A; Phillips, M Y; Rodriguez, S B et al. (1993) Cocaine administration prior to reactivation facilitates later acquisition of an avoidance response in rats. Psychopharmacology (Berl) 112:366-70
Gaensslen, R E; Berka, K M; Herrin Jr, G et al. (1993) Amplification of a genomic sequence in 19th century human bone DNA. Naturwissenschaften 80:80-1
Rodriguez, W A; Rodriguez, S B; Phillips, M Y et al. (1993) Post-reactivation cocaine administration facilitates later acquisition of an avoidance response in rats. Behav Brain Res 59:125-9