Application):
The aim of this investigation is to examine lifetime variation in locomotory ability and the aerobic capacity to support locomotion. Lifetime variation will be considered with respect to age, gender, reproductive status, and febrile effects. The project will ascertain the extent of individual consistency in locomotor performance under different conditions, and whether poor locomotor ability during one part of the lifetime (e.g., young age) is predictive of debilitation at another (e.g., old age). It will also clarify how changes in aerobic capacity and lean mass affect locomotor ability. A rodent model, the house mouse (Mus musculus), will be used for studies of locomotion and aerobic capacity during exercise. Extensive longitudinal studies of locomotor performance, with appropriate controls, will be conducted that would be difficult to conduct with human subjects. There will be tests of locomotor ability (maximal sprint speed, maneuverability, etc.), aerobic capacity, and voluntary performance (which reflects motivation) for individuals of different age and status. One set of tests will compare aging effects on locomotor performance and aerobic capacity for males and females. Among females, there will be additional tests of effects of reproductive condition (non-reproductive, pregnant, lactation, post-reproductive) on locomotor performance. Lastly, there will be tests of the effect of short-term fever on locomotor ability and aerobic capacity. These studies will measure the extent of variation in locomotor responses during the lifetime, and whether future performance capabilities can be assessed from current abilities.
| Ramírez-Camejo, Luis A; Maldonado-Morales, Génesis; Bayman, Paul (2017) Differential Microbial Diversity in Drosophila melanogaster: Are Fruit Flies Potential Vectors of Opportunistic Pathogens? Int J Microbiol 2017:8526385 |
| Morales-Rivera, Keyla F; Piñero Cruz, Dalice M; Prieto, Jose A (2017) Crystal structure of (-)-(S)-4-[(2S,3S,4S,Z)-3-hydroxy-4-methyl-hept-5-en-2-yl]-1,3-dioxolan-2-one. Acta Crystallogr E Crystallogr Commun 73:1070-1072 |
| García-Arriaga, Marilyn; Acosta-Santiago, Maxier; Cruz, Antony et al. (2017) Probing the Limits of Supramolecular G-Quadruplexes Using Atomistic Molecular Dynamics Simulations. Inorganica Chim Acta 468:209-222 |
| Huang, Qing; Quiñones, Edwin (2016) A spectroscopic method to determine the activity of the restriction endonuclease EcoRV that involves a single reaction. Anal Biochem 497:103-5 |
| Mège, Pascal; Schizas, Nikolaos V; Reyes, Joselyd García et al. (2015) Genetic seascape of the threatened Caribbean elkhorn coral, Acropora palmata, on the Puerto Rico Shelf. Mar Ecol (Berl) 36:195-209 |
| Morales-Rivera, Amarilys; Hernández-Burgos, Mayté M; Martínez-Rivera, Arlene et al. (2014) Anxiolytic effects of oxytocin in cue-induced cocaine seeking behavior in rats. Psychopharmacology (Berl) 231:4145-55 |
| Ramírez-Camejo, Luis A; Torres-Ocampo, Ana P; Agosto-Rivera, José L et al. (2014) An opportunistic human pathogen on the fly: strains of Aspergillus flavus vary in virulence in Drosophila melanogaster. Med Mycol 52:211-9 |
| Martínez-Rivera, Arlene; Rodríguez-Borrero, Enrique; Matías-Alemán, María et al. (2013) Metabotropic glutamate receptor 5 within nucleus accumbens shell modulates environment-elicited cocaine conditioning expression. Pharmacol Biochem Behav 110:154-60 |
| Galindo-Cardona, Alberto; Acevedo-Gonzalez, Jenny P; Rivera-Marchand, Bert et al. (2013) Genetic structure of the gentle Africanized honey bee population (gAHB) in Puerto Rico. BMC Genet 14:65 |
| Santiago-Rodriguez, Tasha M; Rivera, Jessica I; Coradin, Mariel et al. (2013) Antibiotic-resistance and virulence genes in Enterococcus isolated from tropical recreational waters. J Water Health 11:387-96 |
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