Funds are requested to aid in the purchase of a high-field nuclear magnetic resonance (NMR) spectrometer to be used by a user group of seven (7) major principals representing four (4) departments. Central to the theme of the research that will be coordinated by the purchase of this instrument is macromolecular structural characterization by a variety of high resolution NMR spectroscopy techniques. The majority of the systems to be characterised are biologically active oligopeptides and proteins with the addition of the binding of antitumor drugs to DNA. The opportunity offered by the NMR technique to probe structures of this complexity is unique and hence the significance of this research is that these studies will give fundamental information concerning the mode of action of these biomolecules.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Grants (S07)
Project #
2S07RR005688-22
Application #
3516180
Study Section
Special Emphasis Panel (NSS)
Project Start
1979-04-01
Project End
1991-03-31
Budget Start
1990-04-06
Budget End
1991-03-31
Support Year
22
Fiscal Year
1990
Total Cost
Indirect Cost
Name
New York Blood Center
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10065