Justifications are presented for the purchase of an x-ray diffractometer and an associated computer system. This instrumentation would be used by the students, postdoctoral associates and faculty who conduct research in Inorganic, Organic and Biological Chemistry. Included are seven groups with PHS support. The scope of the research includes (a) models for zinc finger proteins, (b) synthetic analogs for iron-sulfur clusters and nickel- cysteine centers, (c) synthesis of natural products using organometallic reagents, (d) synthesis of polyazamacrocycles and binding of charged and neutral guests, (e) transition metal-catalyzed oxidation of organic compounds, (f) complementary studies involving solid-state NMR and x-ray diffraction (g) chemistry of metal-carbon multiple bonds. (h) design of supramolecular structure via hydrogen bonds (i) adamantanes as stereochemical and mechanistic probes.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Grants (S07)
Project #
2S07RR005899-09
Application #
3517075
Study Section
Special Emphasis Panel (NSS)
Project Start
1982-04-01
Project End
1991-03-31
Budget Start
1990-04-06
Budget End
1991-03-31
Support Year
9
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115