Funding is requested for a cryogenically cooled probe, preamplifier and helium recovery system for our shared 600 MHz NMR spectrometer. The addition of this cooled probe will greatly facilitate the research of the several research groups that are using or plan to use modern NMR techniques in their work. These groups are working on a wide range of projects that include investigations of the structure, function and dynamics of the proteins involved in bacterial signaling during bacterial chemotaxis and related signaling pathways; protein folding dynamics and the nature of the unfolded state; the structure of self assembly of RNA-RNA recognition units, the coupling of protein dynamics and catalysis in the bacterial DNA cytosine methyltransferase, structural studies of the proteins involved in the epigenetic control of the expression of genes that encode proteins present in pyelonephritis-associated pili; the structure an assembly of tau protein; structural elucidation of marine siderophores; proteins and models of biomineralization; and kinetic analysis of the acetylcholine transporter. ? ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR020900-01
Application #
6877294
Study Section
Special Emphasis Panel (ZRG1-BPC-L (30))
Program Officer
Tingle, Marjorie
Project Start
2005-02-15
Project End
2006-02-14
Budget Start
2005-02-15
Budget End
2006-02-14
Support Year
1
Fiscal Year
2005
Total Cost
$285,538
Indirect Cost
Name
University of California Santa Barbara
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
094878394
City
Santa Barbara
State
CA
Country
United States
Zip Code
93106
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Kawamura, Tetsuya; Le, Lisa Uyen K; Zhou, Hongjun et al. (2007) Solution structure of Escherichia coli PapI, a key regulator of the pap pili phase variation. J Mol Biol 365:1130-42