The population of women with AIDS continues to increase as a consequence of changes in the epidemiology of HIV infection. Currently it is a leading cause of death amongst young women in the United States where the largest increase in incidence of HIV infection is in the African-American and Hispanic populations. HIV associated dementia (HAD) continues to be one of the major complications of AIDS and little is known about the factors that determine HAD in women. Therefore, this population poses several challenges in the evaluation of biological factors and hormonal modifiers, which can impact on the development and severity of HAD in women. At the University of Puerto Rico Medical Sciences Campus we have the unique opportunity to study Hispanic women with HIV infection. We have designed a cross sectional study that will identify HIV infected women at high risk of developing HAD and will determine if gonadal dysfuction and oxidative stress contribute to the dementia. We therefore propose to: a) recruit a cohort of HIV infected women and characterize their neurological and neuropsychological status, b) determine if gonadal hormone dysfunction is associated with HAD, and c) determine the contribution of CSF markers of oxidative stress and HAD. We have chosen these parameters since they are most amenable to therapeutic intervention. Potential drugs that could be used to correct these abnormalities are or can be made available in depot forms that could be used even in less compliant patient populations. Our long-range goal is to develop methods for the early diagnosis, prevention, and treatment of HIV Associated Dementia in the Puerto Rican women population.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Minority Biomedical Research Support Thematic Project Grants (S11)
Project #
5S11NS046278-05
Application #
7490017
Study Section
Special Emphasis Panel (ZNS1-SRB-A (11))
Program Officer
Wong, May
Project Start
2004-07-01
Project End
2011-06-30
Budget Start
2008-07-01
Budget End
2011-06-30
Support Year
5
Fiscal Year
2008
Total Cost
$314,919
Indirect Cost
Name
University of Puerto Rico Med Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
00936
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Morales, Diana; Hechavarria, Rosa; Wojna, Valerie et al. (2013) YWHAE/14-3-3?: a potential novel genetic risk factor and CSF biomarker for HIV neurocognitive impairment. J Neurovirol 19:471-8
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Bandaru, Veera Venkata Ratnam; Mielke, Michelle M; Sacktor, Ned et al. (2013) A lipid storage-like disorder contributes to cognitive decline in HIV-infected subjects. Neurology 81:1492-9
Agsalda-Garcia, Melissa; Shiramizu, Bruce; Melendez, Loyda et al. (2013) Different levels of HIV DNA copy numbers in cerebrospinal fluid cellular subsets. J Health Care Poor Underserved 24:8-16
Morales, Diana; Skoulakis, Efthimios C M; Acevedo, Summer F (2012) 14-3-3s are potential biomarkers for HIV-related neurodegeneration. J Neurovirol 18:341-53
Gerena, Yamil; Skolasky, Richard L; Velez, Joyce M et al. (2012) Soluble and cell-associated insulin receptor dysfunction correlates with severity of HAND in HIV-infected women. PLoS One 7:e37358
Morales, Diana; Acevedo, Summer F; Skolasky, Richard L et al. (2012) Translational spatial task and its relationship to HIV-associated neurocognitive disorders and apolipoprotein E in HIV-seropositive women. J Neurovirol 18:488-502
Oquendo-Jiménez, Ilia; Mena, Rafaela; Antoun, Mikhail D et al. (2010) Linguistic adaptation of the clinical dementia rating scale for a Spanish-speaking population: a focus group approach. P R Health Sci J 29:102-8

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