?Discovery of Natural Products from Botanical Sources? DESCRIPTION This research is designed to explore anticancer agents from plants. A number of U.S. FDA new drug application (NDA) approvals are from unmodified natural products from plants, synthetic derivatives of plant natural products, and refined plant extracts marketed as a ?botanical drug product?. Plants are therefore a rich source of structurally distinct chemical classes with proven utility against disease. In fact, the World Health Organization (WHO) estimates that 65% of the world?s population relies mainly on plant-derived traditional medicines for their primary care. A critical barrier to the progression of phytochemical research, however, is the vast number of plant species unexplored for novel bioactive compounds. This research proposal describes an approach to discover cytotoxic agents from plants.
The specific aims of the proposal are as follows: (1) To prioritize samples using cytotoxicity screening, 1H NMR and mass spectrometry to dereplicate known compounds. (2) To employ cytotoxicity-guided isolation towards the discovery of pure lead compounds. (3) To employ comprehensive NMR-based organic structure analysis in the elucidation of isolated lead compounds.

Public Health Relevance

?Discovery of Natural Products from Botanical Sources? Plants are a rich source of structurally distinct chemical classes with proven utility against human disease. It is the overall goal of this research to discover novel chemicals from selected tropical plant species for evaluation as anticancer agents.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Pilot Research Project (SC2)
Project #
5SC2GM122721-02
Application #
9564152
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Fabian, Miles
Project Start
2017-09-12
Project End
2020-08-31
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
California State University-Dominguez Hills
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
103895579
City
Carson
State
CA
Country
United States
Zip Code
90747