? ? In recent years, genomics and proteomics have emerged as key technologies in biomedical research, ? resulting in a surge of interest in training by investigators keen to utilize these technologies in their research. Use of these advanced technologies requires trained personnel in order to produce valuable results, quality publications, and superior grant applications. To be of maximum benefit, education should ideally occur before experiments are begun, in order to lessen the possibility that the wrong platform is chosen. For example, a first step toward integrating """"""""omics"""""""" technologies is the development of a well-stated hypothesis which clearly defines the research question under investigation. In order to test the hypothesis, the researcher must choose which platform to utilize and this requires an understanding of the technology available and the strengths and weaknesses of each approach. Alternatively, an investigator may determine that a combination of genomics and proteomics approaches is necessary. Careful experimental design is then critical to the success of the project as well as for interpreting the results. Given the large datasets generated by these technologies, knowledge of biostatistics, data analysis, and bioinformatics are vital and these are areas in which many investigators require additional training, specifically in the context of """"""""omics"""""""" research. To address the issues outlined above, at least two types of training in """"""""omics"""""""" technologies can be ? envisioned: 1) immediate, short-term training in the form of workshops, and 2) long-term, comprehensive instruction in the form of graduate education programs. The current proposal aims to fill the former need by providing hands-on training in genomics and proteomics in a coherent, experimentally-based framework. The Directors of the proposal have developed and taught courses covering Proteomics, Genomics, Bioinformatics, and Biostatistics and the curriculum for the proposed course will merge their expertise to provide a comprehensive training overview of these key technologies. Specifically, we propose to accomplish the following: build a curriculum enabling outcome-structured learning in proteomics and genomics technologies, provide novel training experiences using hands-on techniques and an established model by experienced investigators and educators, disseminate educational materials such that knowledge and information can be used to benefit a wide variety of audiences, and provide and/or act as portal for collaborative opportunities for both young and established investigators. ? ? (End of Abstract) ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Continuing Education Training Grants (T15)
Project #
5T15HL086386-02
Application #
7284295
Study Section
Special Emphasis Panel (ZHL1-CSR-O (S2))
Program Officer
Applebaum-Bowden, Deborah
Project Start
2006-09-05
Project End
2010-08-31
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
2
Fiscal Year
2007
Total Cost
$142,057
Indirect Cost
Name
University of Colorado Denver
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Reisdorph, Nichole; Stearman, Robert; Kechris, Katerina et al. (2013) Hands-on workshops as an effective means of learning advanced technologies including genomics, proteomics and bioinformatics. Genomics Proteomics Bioinformatics 11:368-77
Savage, William J; Barron-Casella, Emily; Fu, Zongming et al. (2011) Plasma glial fibrillary acidic protein levels in children with sickle cell disease. Am J Hematol 86:427-9
Wynes, Murry W; Edelman, Benjamin L; Kostyk, Amanda G et al. (2011) Increased cell surface Fas expression is necessary and sufficient to sensitize lung fibroblasts to Fas ligation-induced apoptosis: implications for fibroblast accumulation in idiopathic pulmonary fibrosis. J Immunol 187:527-37
Bembea, Melania M; Savage, William; Strouse, John J et al. (2011) Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation. Pediatr Crit Care Med 12:572-9
Fu, Qin; Schoenhoff, Florian S; Savage, William J et al. (2010) Multiplex assays for biomarker research and clinical application: translational science coming of age. Proteomics Clin Appl 4:271-84