The Bowles Center for Alcohol Studies (CAS) training program at the University of North Carolina at Chapel Hill is designed to promote the development of promising postdoctoral research fellows as independent investigators and future University faculty members who will investigate the pathogenesis of alcoholism and alcohol abuse using modern molecular medicine, biochemical and imaging techniques. Training of the postdoctoral fellows will be individualized with the most important component being the research conducted by the trainee in the faculty mentor's laboratory. In addition to hand's-on alcohol research, additional training will include didactic courses, seminars and conferences, activities on responsible conduct of research and other training as needed to prepare fellows for independent research. The training faculty will consist of 14 funded investigators from multiple departments at the University of North Carolina at Chapel Hill. The faculty has a documented history of close interaction and collaboration. The trainees will benefit from the unique strengths of alcohol research at the University of North Carolina, which include the CAS with its research cores, UNC-Neuroscience Center, a research-oriented Mental Health Research Center with its research cores in Psychiatry, a CTSA and the Program in Molecular Biology and Biotechnology. The training program will be directed by Dr. Fulton T. Crews with the assistance of three senior alcohol researchers, Drs. Clyde Hodge, Kathy Sulik and Leslie Morrow, who will constitute the Training Program Advisory Committee. The program proposes six post-doctoral fellow slots. Trainees will receive two years of research training with the possibility of a third year and with external support sought for later years. This institutional training grant will promote intensive training in molecular, biochemical and imaging techniques and basic pathophysiology in a stimulating environment leading to broadly trained independent investigators capable of adapting to the rapid advances in research in the 21st century.

Public Health Relevance

The goals of this Grant are to train new alcohol research scientists. Training new scientists in alcohol research methods is essential to understanding the complex nature of binge drinking. Multi-disciplinary training in molecular mechanisms of alcoholic pathology will cover fetal, brain, genetic, behavioral and other pathologies involved in long term drinking.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
3T32AA007573-17S1
Application #
8836649
Study Section
Special Emphasis Panel (ZAA1 (32))
Program Officer
Grandison, Lindsey
Project Start
1997-04-01
Project End
2018-03-31
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
17
Fiscal Year
2014
Total Cost
$59,381
Indirect Cost
$4,399
Name
University of North Carolina Chapel Hill
Department
Pharmacology
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Broadwater, Margaret A; Lee, Sung-Ho; Yu, Yang et al. (2018) Adolescent alcohol exposure decreases frontostriatal resting-state functional connectivity in adulthood. Addict Biol 23:810-823
Hwa, Lara S; Neira, Sofia; Pina, Melanie M et al. (2018) Predator odor increases avoidance and glutamatergic synaptic transmission in the prelimbic cortex via corticotropin-releasing factor receptor 1 signaling. Neuropsychopharmacology :
Coleman Jr, Leon G; Zou, Jian; Qin, Liya et al. (2018) HMGB1/IL-1? complexes regulate neuroimmune responses in alcoholism. Brain Behav Immun 72:61-77
Mazzone, C M; Pati, D; Michaelides, M et al. (2018) Acute engagement of Gq-mediated signaling in the bed nucleus of the stria terminalis induces anxiety-like behavior. Mol Psychiatry 23:143-153
Harper, Kathryn M; Knapp, Darin J; Park, Meredith A et al. (2017) Age-related differences in anxiety-like behavior and amygdalar CCL2 responsiveness to stress following alcohol withdrawal in male Wistar rats. Psychopharmacology (Berl) 234:79-88
Massey, Veronica; Cabezas, Joaquin; Bataller, Ramon (2017) Epigenetics in Liver Fibrosis. Semin Liver Dis 37:219-230
Crews, Fulton T; Lawrimore, Colleen J; Walter, T Jordan et al. (2017) The role of neuroimmune signaling in alcoholism. Neuropharmacology 122:56-73
Vetreno, Ryan P; Patel, Yesha; Patel, Urvi et al. (2017) Adolescent intermittent ethanol reduces serotonin expression in the adult raphe nucleus and upregulates innate immune expression that is prevented by exercise. Brain Behav Immun 60:333-345
Elton, Amanda; Smith, Christopher T; Parrish, Michael H et al. (2017) Neural Systems Underlying Individual Differences in Intertemporal Decision-making. J Cogn Neurosci 29:467-479
Vetreno, Ryan P; Yaxley, Richard; Paniagua, Beatriz et al. (2017) Adult rat cortical thickness changes across age and following adolescent intermittent ethanol treatment. Addict Biol 22:712-723

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