This application constitutes the first renewal of the NIAAA Pre and Postdoctoral Training Program that is specifically designed to promote the training in cellular and molecular research on how alcohol sensitizes and primes the liver and pancreas for the development of alcoholic liver and pancreas diseases (ALPD). Our program is integrated into the NIAAA Alcohol Research Center: USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases that is now in the second cycle of funding as of January 2004. The Center's interactive infrastructure and supportive mechanisms are conducive to providing an ideal training environment for the program. In addition to laboratory training, the Program provides didactic courses including a 2-unit seminar course (Path575), lectures on liver and pancreatic histology (INT550), lectures on pathogenesis and pathophysiology of ALPD (INT551), and a course in Scientific Ethics (INTD500) offered at USC. The trainee's progress is monitored in the Progress Report Meeting held once or twice yearly. In this meeting, the trainees and the Center's pilot project investigators update their progresses that are evaluated by the Center's Executive Committee. In the Center's Annual Symposium, the trainees make more formal presentations and their individual training status and the program as a whole are evaluated by the External Scientific Advisory Board members. Of 12 slots requested originally, 11 slots have been filled including one predoctoral position. Of 7 trainees who have completed the training to date, three have been or will be promoted to Assistant Professor. Two of them have obtained pilot project funds to prepare for their independent research in the field of alcoholic liver disease. A total of 11 peer-review articles have been published, in press, or accepted for publication for the studies in which the 7 past trainees were involved. In the proposed renewal, we request 12 postdoctoral and 2 predoctoral slots to continue our pursuit for the comprehensive and cutting-edge training to generate competent and innovative young scientists in the field of ALPD.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA007578-10
Application #
7619306
Study Section
Special Emphasis Panel (ZAA1-HH (01))
Program Officer
Radaeva, Svetlana
Project Start
2000-05-01
Project End
2011-04-30
Budget Start
2009-05-01
Budget End
2011-04-30
Support Year
10
Fiscal Year
2009
Total Cost
$183,170
Indirect Cost
Name
University of Southern California
Department
Pathology
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Xu, Jun; Lai, Keane K Y; Verlinsky, Alla et al. (2011) Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol 55:673-682
Lai, Keane K Y; Jin, Ming; Yuan, Shan et al. (2011) Improved reflexive testing algorithm for hepatitis C infection using signal-to-cutoff ratios of a hepatitis C virus antibody assay. Clin Chem 57:1050-6
Than, Tin Aung; Lou, Huan; Ji, Cheng et al. (2011) Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem 286:22047-54
Yeligar, Samantha M; Machida, Keigo; Kalra, Vijay K (2010) Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression. J Biol Chem 285:35359-73
Yeligar, Samantha M; Machida, Keigo; Tsukamoto, Hidekazu et al. (2009) Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol 183:5964-76
Yeligar, Samantha; Tsukamoto, Hidekazu; Kalra, Vijay K (2009) Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. J Immunol 183:5232-43
Lu, Shelly C; Ramani, Komal; Ou, Xiaopeng et al. (2009) S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model. Hepatology 50:462-71
Tomasi, Maria Lauda; Iglesias-Ara, Ainhoa; Yang, Heping et al. (2009) S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis. Gastroenterology 136:1025-36
Ramani, Komal; Yang, Heping; Xia, Meng et al. (2008) Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta. Hepatology 47:521-31
Ara, Ainhoa Iglesias; Xia, Meng; Ramani, Komal et al. (2008) S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation. Hepatology 47:1655-66

Showing the most recent 10 out of 27 publications